5-Amino-1MQ
A small molecule NNMT inhibitor studied for its effects on fat cell metabolism and energy expenditure.
Overview
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue of obese individuals. By inhibiting NNMT, it increases cellular NAD+ levels and promotes a shift toward energy expenditure and reduced fat storage.
The following information summarizes peer-reviewed research on 5-Amino-1MQ. Study descriptions reflect published findings, e.g., "animal studies have investigated," "cellular studies suggest," or "clinical trials have evaluated", and do not constitute therapeutic claims.
Mechanism of Action
5-Amino-1MQ inhibits NNMT, which normally converts nicotinamide to 1-methylnicotinamide while consuming SAM (S-adenosylmethionine). Inhibition increases intracellular NAD+ pools, activating SIRT1 and other NAD+-dependent enzymes that promote fat oxidation and mitochondrial biogenesis.
Research Evidence
5-Amino-1MQ. Evidence Summary
Too few studies to assess evidence strength
Evidence Level 1: Early Research, Very limited published research. May include only 1–2 preliminary laboratory or theoretical studies.
Study Type Distribution
0
Human Studies
0
Animal Studies
0
In Vitro
0
Reviews
Research Coverage
Last PubMed Ingestion
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Research Timeline
Chronological progression of 5-Amino-1MQ research, auto-generated from 4 indexed publications.
Kraus et al. (2014). Established NNMT as a therapeutic target for metabolic disease.
Research on 5-Amino-1MQ
NNMT inhibition increases NAD+ and reduces fat cell size
Biochemical Pharmacology
Demonstrated that NNMT inhibition by 5-amino-1MQ increases cellular NAD+ and reduces adipocyte size.
Neelakantan et al. (2018). Showed reduction in body weight and adipocyte size in diet-induced obese mice.
Research on 5-Amino-1MQ
Brachs et al. (2019). Demonstrated NNMT's role in adipose tissue metabolism and obesity.
Research on 5-Amino-1MQ
Conditions Studied
Research Studies
Neelakantan, H. et al
Neelakantan, H
et al. Biochemical Pharmacology, 2018
Referenced study on 5-Amino-1MQ investigating obesity and metabolic research.
5-Amino-1MQ research — Kraus, D
Kraus, D
et al. Nature, 2014
Referenced study on 5-Amino-1MQ investigating obesity and metabolic research.
Study Highlights
NNMT inhibition increases NAD+ and reduces fat cell size
Neelakantan H, Vance V, Wetzel MD, et al. · Biochemical Pharmacology, 2018
Demonstrated that NNMT inhibition by 5-amino-1MQ increases cellular NAD+ and reduces adipocyte size.
References
1 peer-reviewed publication referenced in this 5-Amino-1MQ research overview. 1 linked to PubMed or DOI.
Further Reading
Scientific Context
This page summarizes published scientific research on 5-Amino-1MQ. Many peptides discussed on this site are experimental research compounds that have not been approved for clinical use. The research presented here is sourced from peer-reviewed journals and indexed databases such as PubMed. Evidence levels and study counts reflect the quantity and type of available research, not efficacy or safety endorsements.
This content is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making any health-related decisions.
Learn about our editorial standards →Research Transparency
PSI functions as a transparent research index. All research information is sourced from peer-reviewed scientific literature and automatically indexed from PubMed/MEDLINE. Every study displayed includes verifiable source references. PubMed ID, journal, authors, and publication year, allowing independent verification. PSI does not make therapeutic claims; all content summarizes published research findings.
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Published: January 15, 2025
Updated: March 1, 2026
This content is for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before making any health decisions.