Research Index
Trofinetide (Daybue) Research Index
PSI surfaces 30 peer-reviewed studies on Trofinetide (Daybue), prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
30 studies
Enhanced Effectiveness of Onabotulinum Toxin A in Combination With Definisse KP1 Eye Contour Cream for Upper Face Rejuvenation: A Case Series.
Proietti I, Manni M
J Cosmet Dermatol ·2026·Human·Skin & Cosmetic·PubMed →
Effects of Botulinum Toxin Type A and Argireline on Dermal Collagen Remodeling and Skin Biology in a Flap Model.
Acuner B, Görgülü T, Işıktekin E et al.
Aesthetic Plast Surg·2026·Animal·PubMed →
DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging.
Bai D, Wang Z, Liu T et al.
Biomater Adv·2026·Animal·Skin & Cosmetic, Wound Healing·PubMed →
Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.
Dikmen Kucuk S, Jabet P, Groso A et al.
Int J Cosmet Sci·2026·Animal·Skin & Cosmetic·PubMed →
BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model.
Jiang X, Wang W, Wei Y et al.
J Cosmet Dermatol·2025·Animal·Anti-Inflammatory, Wound Healing·PubMed →
Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits.
Edison BL, Parsa R, Dufort M et al.
J Drugs Dermatol·2025·Animal·Anti-Inflammatory, Skin & Cosmetic, Wound Healing·PubMed →
INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections.
Lupin M, Bjerring P, Andriessen A et al.
J Drugs Dermatol·2024·Animal·Skin & Cosmetic·PubMed →
Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.
Olsson SE, Sreepad B, Lee T et al.
JMIR Dermatol·2024·Animal·PubMed →
Influence of the modification of the cosmetic peptide Argireline on the affinity toward copper(II) ions.
Wyrzykowski D, Wieczorek R, Kloska A et al.
J Pept Sci·2024·Animal·PubMed →
Cosmeceuticals in photoaging: A review.
Chan LKW, Lee KWA, Lee CH et al.
Skin Res Technol·2024·Review·Skin & Cosmetic, Wound Healing·PubMed →
Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.
Velazco de Maldonado GJ, Suárez-Vega DV, Miller-Kobisher B et al.
J Cutan Aesthet Surg·2023·Animal·PubMed →
Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia(®) Complexion Analysis camera system for objective skin analysis.
Henseler H
GMS Interdiscip Plast Reconstr Surg DGPW·2023·Animal·PubMed →
Complications and adverse effects of periocular aesthetic treatments.
Nagendran ST, Ali MJ, Dogru M et al.
Surv Ophthalmol·2022·Review·PubMed →
Mycobacterium abscessus infection after facial injection of argireline: A case report.
Chen CF, Liu J, Wang SS et al.
World J Clin Cases·2021·Human·PubMed →
3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes.
Mestre R, García N, Patiño T et al.
Biofabrication·2021·Animal·Longevity, Muscle Recovery·PubMed →
Argireline: Needle-Free Botox as Analytical Challenge.
Kluczyk A, Ludwiczak J, Modzel M et al.
Chem Biodivers·2021·Animal·Skin & Cosmetic·PubMed →
Combination Tripeptide/Hexapeptide Serum with 1540 nm Nonablative Fractional Laser for the Treatment of Striae Distensae: A Pilot Study.
McGuinn KP, Ross NA, Wang JV et al.
Skinmed·2020·Human·PubMed →
Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8.
Palmieri B, Noviello A, Corazzari V et al.
Clin Ter·2020·Animal·Wound Healing, Skin & Cosmetic·PubMed →
Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification.
Lim SH, Sun Y, Thiruvallur Madanagopal T et al.
Sci Rep·2018·Animal·PubMed →
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study.
Raikou V, Varvaresou A, Panderi I et al.
J Cosmet Dermatol·2017·Human·Skin & Cosmetic·PubMed →
Topical delivery of acetyl hexapeptide-8 from different emulsions: influence of emulsion composition and internal structure.
Hoppel M, Reznicek G, Kählig H et al.
Eur J Pharm Sci·2015·Animal·Wound Healing·PubMed →
In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.
Kraeling ME, Zhou W, Wang P et al.
Cutan Ocul Toxicol·2015·Animal·Skin & Cosmetic, Wound Healing·PubMed →
Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.
Krishnan G, Roberts MS, Grice J et al.
Drug Deliv Transl Res·2014·Animal·PubMed →
The study of cellular cytotoxicity of argireline - an anti-aging peptide.
Grosicki M, Latacz G, Szopa A et al.
Acta Biochim Pol·2014·Animal·Longevity, Tissue Remodeling, Skin & Cosmetic·PubMed →
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.
Wang Y, Wang M, Xiao S et al.
Am J Clin Dermatol·2013·Human·Skin & Cosmetic·PubMed →
Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.
Lungu C, Considine E, Zahir S et al.
Eur J Neurol·2013·Human·PubMed →
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects.
Wang Y, Wang M, Xiao XS et al.
J Cosmet Laser Ther·2013·Animal·PubMed →
The anti-wrinkle efficacy of Argireline.
Wang Y, Wang M, Xiao XS et al.
J Cosmet Laser Ther·2013·Animal·Wound Healing, Skin & Cosmetic·PubMed →
Preparation and stability of cosmetic formulations with an anti-aging peptide.
Ruiz MA, Clares B, Morales ME et al.
J Cosmet Sci·2007·Animal·Skin & Cosmetic·PubMed →
A synthetic hexapeptide (Argireline) with antiwrinkle activity.
Blanes-Mira C, Clemente J, Jodas G et al.
Int J Cosmet Sci·2002·Animal·PubMed →