Research Index
Thymosin Alpha-1 Research Index
PSI surfaces 62 peer-reviewed studies on Thymosin Alpha-1, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
62 studies
Thymosin α1 improves the outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure by restoring immune balance.
Li ZH, Wu LL, Zhu YQ et al.
Immunopharmacol Immunotoxicol·2026·Human·Anti-Inflammatory·PubMed →
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial.
Xu H, Li F, Li B et al.
BMC Med·2026·Human·PubMed →
A Case Report of a Multisystemic Immune-Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha-1.
Li T, Wu BL, Yu CL et al.
Clin Case Rep·2026·Human·PubMed →
Unveiling lymphocyte dynamics: Navigating postoperative immune landscapes in gastric cancer patients undergoing laparoscopic D2 gastrectomy.
Gao C, Zhu L, Tong YX et al.
Int J Immunopathol Pharmacol·2025·Human·PubMed →
Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis.
Tian Y, Yao J, Ma Y et al.
Front Immunol·2025·Human·Anti-Inflammatory·PubMed →
Effect of thymosin α1 on Immune response and organ function in acute aortic dissection surgery: PANDA II trial protocol.
Liu H, Qian SC, Zhang YY et al.
Future Cardiol·2025·Human·PubMed →
Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter Phase II clinical trial.
Yu J, Yin L, Guo W et al.
Cancer Immunol Immunother·2025·Human·PubMed →
Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.
Aynekulu Mersha DG, Fromme SE, van Boven F et al.
Brain Behav Immun Health·2025·Human·PubMed →
The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.
Wu J, Pei F, Zhou L et al.
BMJ·2025·Human·PubMed →
PD-1 inhibitor combined with SBRT, GM-CSF, and thymosin alpha-1 in metastatic breast cancer: A case report and literature review.
Yu J, Wang Q, Wang L et al.
Medicine (Baltimore)·2024·Human·PubMed →
Effect of thymalfasin on myeloid-derived suppressor cells in patients with non-small cell lung cancer.
Shi F, Qiu H, Yan J et al.
Am J Transl Res·2024·Human·PubMed →
Evaluation of the efficacy and safety of a precise thymalfasin-regulated PRaG regimen for advanced refractory solid tumours: protocol for the open-label, prospective, multicentre study (PRaG5.0 study).
Kong Y, Chen R, Xu M et al.
BMJ Open·2024·Human·PubMed →
Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A Post Hoc Analysis of a Randomized Clinical Trial.
Huang X, Mao W, Hu X et al.
Gut Liver·2024·Human·Metabolic Syndrome·PubMed →
A Prospective and Randomized Control Study on Effects of Thymalfasin for Injection on Perioperative Immune Function and Long-term Prognosis of Patients with Colorectal Cancer.
Niu W, Li Z, Li Z et al.
Biotechnol Genet Eng Rev·2024·Human·PubMed →
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression.
Soeroto AY, Suryadinata H, Yanto TA et al.
Inflammopharmacology·2023·Human·PubMed →
Thymosin α1 modulated the immune landscape of COVID-19 patients revealed by single-cell RNA and TCR sequencing.
Bai H, Liang L, Qi X et al.
Int Immunopharmacol·2023·Human·PubMed →
Risk Factors and Drug Efficacy for Severe Illness in Hemodialysis Patients Infected with the Omicron Variant of COVID-19.
Wu Y, He L, Guo Y et al.
Kidney Blood Press Res·2023·Human·PubMed →
Palliative care and Chinese medicine in a centenarian with primary hepatocellular carcinoma and 27-month follow-up: A case report.
Hu Y, Lan XH, Cao YJ et al.
Heliyon·2023·Human·PubMed →
Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?
Manusama O, Singh S, Brooimans RA et al.
Int Immunopharmacol·2023·Human·Anti-Inflammatory·PubMed →
Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trial.
Ke L, Mao W, Shao F et al.
EClinicalMedicine·2023·Human·PubMed →
A pilot trial of Thymalfasin (Ta1) to prevent covid-19 infection and morbidities in renal dialysis patients: Preliminary report.
Tuthill CW, Awad A, Parrigon M et al.
Int Immunopharmacol·2023·Human·PubMed →
Thymosin alpha1 use in adult COVID-19 patients: A systematic review and meta-analysis on clinical outcomes.
Shang W, Zhang B, Ren Y et al.
Int Immunopharmacol·2023·Human·PubMed →
A randomized controlled pilot trial of etanercept and alpha-1 antitrypsin to improve autologous islet engraftment.
Abdel-Karim TR, Hodges JS, Pruett TL et al.
Pancreatology·2023·Human·PubMed →
A Pilot Trial of Thymalfasin (Thymosin-α-1) to Treat Hospitalized Patients With Hypoxemia and Lymphocytopenia Due to Coronavirus Disease 2019 Infection.
Shehadeh F, Benitez G, Mylona EK et al.
J Infect Dis·2023·Human·PubMed →
Value of Thymosin α1 Combined With Blood Purification to Increase Successful Rescues of Shock Patients.
Bai L, Qiu X, Ding X et al.
Altern Ther Health Med·2022·Human·Anti-Inflammatory·PubMed →
Efficacy of Thymosin α1 in Management of Radiation Pneumonitis in Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiotherapy: A Phase 2 Clinical Trial (GASTO-1043).
Liu F, Qiu B, Xi Y et al.
Int J Radiat Oncol Biol Phys·2022·Human·PubMed →
Clinical effect of Xuebijing combined with thymosinα1 on patients with severe pneumonia complicated with sepsis and its effect on serum inflammatory factors.
Chen Y, Zhou L, Wang J et al.
Cell Mol Biol (Noisy-le-grand)·2022·Human·Anti-Inflammatory·PubMed →
Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial.
Ke L, Zhou J, Mao W et al.
Intensive Care Med·2022·Human·PubMed →
Safety and efficacy of Thymosin α1 in the treatment of hepatitis B virus-related acute-on-chronic liver failure: a randomized controlled trial.
Chen JF, Chen SR, Lei ZY et al.
Hepatol Int·2022·Human·PubMed →
Hypofractionated Radiation Therapy Combined With Weekly Chemotherapy in Patients With Unresectable or Recurrent Thymic Epithelial Tumor: A Prospective, Single-Arm Phase 2 Study (GASTO-1042).
Chu C, Liang Y, Lin X et al.
Int J Radiat Oncol Biol Phys·2022·Human·PubMed →
Clinical efficacy of thymosin alpha 1 combined with multi-modality chemotherapy and its effects on immune function of patients with pulmonary tuberculosis complicated with diabetes.
Wu L, Luo PP, Tian YH et al.
Pak J Med Sci·2022·Human·PubMed →
Impact of thymosin α1 as an immunomodulatory therapy on long-term survival of non-small cell lung cancer patients after R0 resection: a propensity score-matched analysis.
Guo CL, Mei JD, Jia YL et al.
Chin Med J (Engl)·2021·Human·PubMed →
Postpartum extracorporeal membrane oxygenation of a woman with COVID-19-related acute respiratory distress syndrome: A case report.
Huang W, Cheng Z, Liao X et al.
Medicine (Baltimore)·2021·Human·PubMed →
Thymosin Alpha-1 Has no Beneficial Effect on Restoring CD4+ and CD8+ T Lymphocyte Counts in COVID-19 Patients.
Wang Z, Chen J, Zhu C et al.
Front Immunol·2021·Human·PubMed →
Efficacy Evaluation of Thymosin Alpha 1 in Non-severe Patients With COVID-19: A Retrospective Cohort Study Based on Propensity Score Matching.
Huang C, Fei L, Xu W et al.
Front Med (Lausanne)·2021·Human·PubMed →
The right immune-modulation at the right time: thymosin α1 for prevention of severe COVID-19 in cancer patients.
Bersanelli M, Giannarelli D, Leonetti A et al.
Future Oncol·2021·Human·PubMed →
Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 Patients.
Matteucci C, Minutolo A, Balestrieri E et al.
Open Forum Infect Dis·2021·Human·PubMed →
Delayed discharge is associated with higher complement C3 levels and a longer nucleic acid-negative conversion time in patients with COVID-19.
Lin P, Chen W, Huang H et al.
Sci Rep·2021·Human·PubMed →
The effect of thymosin α1 on mortality of critical COVID-19 patients: A multicenter retrospective study.
Sun Q, Xie J, Zheng R et al.
Int Immunopharmacol·2021·Human·PubMed →
Epigenetic Therapy Promotes the Ratio of Th1/Th17 Lineage to Reverse Immune Evasion and Treat Leukemia Relapse Post-allogeneic Stem Cell Transplantation in Non-APL AML Patients.
Xi Y, Jingying D, Chenglong L et al.
Front Mol Biosci·2020·Human·PubMed →
Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, placebo-controlled, parallel-group trial.
Zhou J, Mao W, Ke L et al.
BMJ Open·2020·Human·PubMed →
Thymosin α1 therapy in critically ill patients with COVID-19: A multicenter retrospective cohort study.
Wu M, Ji JJ, Zhong L et al.
Int Immunopharmacol·2020·Human·PubMed →
Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.
Liang B, Chen J, Li T et al.
Medicine (Baltimore)·2020·Human·Antimicrobial·PubMed →
CD3(+), CD4(+), and CD8(+) Expression in Cells in Peripheral Blood of Silicosis Patients and Intervention Effect of Thymalfasin.
Xiong W, Liu ZG, Xiong L et al.
Ann Clin Lab Sci·2019·Human·PubMed →
Severe Gastric Mycormycosis Infection Followed by Cytomegalovirus Pneumonia in a Renal Transplant Recipient: A Case Report and Concise Review of the Literature.
Peng H, Xiao J, Wan H et al.
Transplant Proc·2019·Human·PubMed →
The effect of thymopentin add-on in hepatitis B e antigen positive chronic hepatitis B after virus suppression by peginterferon plus entecavir therapy.
Ma Y, Bao X, Xiong F et al.
Cell Mol Biol (Noisy-le-grand)·2019·Human·PubMed →
Chronic active EBV infection associated with NK cell lymphoma and hemophagocytic lymphohistiocytosis in a 27-year-old woman: A case report.
Wang YD, Wu LL, Ma LY et al.
Medicine (Baltimore)·2019·Human·PubMed →
Stereotactic body radiation therapy and thymosin alpha-1-induced anti-tumor effects in heavily pretreated, metastatic esophageal squamous cell carcinoma patients.
Du D, Song T, Dai H et al.
Oncoimmunology·2018·Human·PubMed →
Thymosin alpha 1 treatment for patients with sepsis.
Pei F, Guan X, Wu J
Expert Opin Biol Ther·2018·Human·PubMed →
Combination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study.
Wu X, Shi Y, Zhou J et al.
Expert Opin Biol Ther·2018·Human·PubMed →
The effect of thymosin α1 for prevention of infection in patients with severe acute pancreatitis.
Yang N, Ke L, Tong Z et al.
Expert Opin Biol Ther·2018·Human·PubMed →
Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy.
Danielli R, Cisternino F, Giannarelli D et al.
Expert Opin Biol Ther·2018·Human·PubMed →
[Clinical research on sequential dual-drug nonspecific immunotherapy in patients with hepatocellular carcinoma].
Zhou JP, Yao SY, Chen YY et al.
Zhonghua Gan Zang Bing Za Zhi·2018·Human·PubMed →
Thymosin-α1 expands deficient IL-10-producing regulatory B cell subsets in relapsing-remitting multiple sclerosis patients.
Giacomini E, Rizzo F, Etna MP et al.
Mult Scler·2018·Human·Anti-Inflammatory·PubMed →
[Effect of transcatheter arterial chemoembolization combined with thymosin alpha 1 on the autophagy of immune cells from advanced hepatocellular carcinoma].
Fang SJ, Zheng LY, Zhao ZW et al.
Zhonghua Yi Xue Za Zhi·2017·Human·PubMed →
Effect of ulinastatin combined with thymosin alpha1 on sepsis: A systematic review and meta-analysis of Chinese and Indian patients.
Liu D, Yu Z, Yin J et al.
J Crit Care·2017·Human·PubMed →
Serum thymosin α 1 levels in patients with chronic inflammatory autoimmune diseases.
Pica F, Chimenti MS, Gaziano R et al.
Clin Exp Immunol·2016·Human·Anti-Inflammatory·PubMed →
Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection.
Al-Mahtab M, Bazinet M, Vaillant A
PLoS One·2016·Human·PubMed →
[Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation].
Zhang SS, Li K, Wang YH et al.
Sichuan Da Xue Xue Bao Yi Xue Ban·2015·Human·PubMed →
[Effect of Acupuncture on Prognosis and Immune Function of Sepsis Patients].
Xiao QS, Ma MY, Zhang XS et al.
Zhongguo Zhong Xi Yi Jie He Za Zhi·2015·Human·PubMed →
Thymosin α1 plus routine treatment inhibit inflammatory reaction and improve the quality of life in AECOPD patients.
Jia Z, Feng Z, Tian R et al.
Immunopharmacol Immunotoxicol·2015·Human·Antimicrobial, Anti-Inflammatory·PubMed →
A multicenter, randomized, observation-controlled clinical trial to evaluate the efficacy and safety of thymalfasin adjuvant therapy in patients with HBV-related HCC after curative resection - first announcement of the protocol.
Qiu SJ, Zhou ZG, Shen F et al.
Expert Opin Biol Ther·2015·Human·PubMed →