Research Index
CagriSema Research Index
PSI surfaces 50 peer-reviewed studies on CagriSema, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Stigmasterol alleviates central precocious puberty by targeting the IGF-1/PI3K/Akt/mTOR signaling pathway and modulating the Kisspeptin/GnRH axis.
Dong L, Xing Y, Li X et al.
Biochim Biophys Acta Mol Basis Dis·2027·Animal·GH Activity, Neuroprotection·PubMed →
Hyperkisspeptinemia and hypothalamic-pituitary-gonadal axis uncoupling in hemodialysis patients: clinical evidence suggestive of central desensitization.
Lan N, Ye D, Li M et al.
Clin Kidney J·2026·Human·PubMed →
Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.
Yeung AC, Phylactou M, Koysombat K et al.
Eur J Endocrinol·2026·Human·PubMed →
Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes.
Han L, Wang Y, Li Y et al.
Front Endocrinol (Lausanne)·2026·Human·PubMed →
Serum kisspeptin levels in pregnant and non-pregnant diestrus bitches: a pilot study.
Coppola T, Barbato O, Menchetti L et al.
Front Vet Sci·2026·Human·PubMed →
First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report.
Uyanık G, Yüksel M, Kara F et al.
Vet Res Commun·2026·Human·PubMed →
Identification of a novel KISS1R (GPR54) gene variant (c.505+2T>G) in a patient with congenital hypogonadotropic hypogonadism: A case report and literature review.
Menekse B, Ucgul E, Bakir A et al.
Exp Ther Med·2026·Human·PubMed →
Effect of post-mating TAK-683 (Kisspeptin analog) treatment on luteal morphology and function in suckling goats with lactational anestrus.
Uyanık G, Yüksel M, Abay M et al.
Anim Reprod Sci·2026·Human·PubMed →
Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.
Galbiati F, Plessow F, Plummer L et al.
J Neuroendocrinol·2026·Human·PubMed →
Monosynaptic GABAergic projections from a subset of suprachiasmatic nucleus neuromedin S neurons suppress preoptic area kisspeptin neuron firing in female mice.
Abdulmajeed WI, Neuman PN, Jamieson BB et al.
J Neurosci·2026·Animal·PubMed →
Physiopathology of PMOS from a Neuroendocrine Perspective.
Cotellessa L, Bongiovanni S, Giacobini P
Physiology (Bethesda)·2026·Animal·PubMed →
Kisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling.
Arkalı G, Çay M, Güler Ekmen E et al.
Reprod Sci·2026·Animal·PubMed →
Implications of neuropeptide Y in the regulation of testicular functions in wall lizard, Hemidactylus flaviviridis.
Chauhan V, Rai U, Tripathy M et al.
Comp Biochem Physiol A Mol Integr Physiol·2026·Animal·PubMed →
Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
Spratt JA, Tanday N, McGinn DM et al.
Metabolites·2026·Animal·PubMed →
Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis.
Takács S, Skrapits K, Göcz B et al.
Nat Commun·2026·Animal·Neuroprotection·PubMed →
Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice.
Young LA, Hurtado ER, Jacobs KD et al.
J Neuroendocrinol·2026·Animal·Neuroprotection·PubMed →
Effect of Zinc Status on Pubertal and Cognitive Functions in Male Offspring of Rats with Induced Zinc Deficiency During Gestation and Lactation.
Unal O, Baltaci SB, Gulbahce-Mutlu E et al.
Biol Trace Elem Res·2026·Animal·PubMed →
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
Barbosa EM, Rodrigues NP, Santos BR et al.
Cardiovasc Toxicol·2026·Animal·Tissue Remodeling·PubMed →
Effects of high frequency administration of GnRH or kisspeptin on LH pulse and surge profiles in ovariectomized Bos taurus and Bos indicus heifers†.
eSilva LO, West S, Garza V et al.
Biol Reprod·2026·Animal·PubMed →
Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.
Qiu J, Lin Y, Bartram E et al.
J Neuroendocrinol·2026·Animal·Neuroprotection·PubMed →
Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
Netesa MA, Pyurveev SS, Lebedev AA et al.
In Silico Pharmacol·2026·Animal·PubMed →
Molecular characterization of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in the Djungarian hamster (Phodopus sungorus).
Stewart C, Marshall C, Stevenson TJ
J Neuroendocrinol·2026·Animal·PubMed →
Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.
Jaldhi, Kumar S, Shanker OR et al.
Mol Neurobiol·2026·Animal·PubMed →
Targeting estrogen to the brain via DHED does not seem to protect against metabolic dysfunction in obese OVX mice.
Camon C, Kip E, Lord R et al.
Endocrinology·2026·Animal·Weight Loss·PubMed →
Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.
Macedo DB, Pereira SA, Wang M et al.
J Neuroendocrinol·2026·Animal·Weight Loss·PubMed →
Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
Gemici Sinen A, Savran E, Güleç OB et al.
Turk J Med Sci·2026·Animal·PubMed →
Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.
Korkmaz O, Karabulut S, Macit P
J Assist Reprod Genet·2026·Animal·PubMed →
Effects of Maternal Zinc Deficiency and Post-Weaning Zinc Status on Neuroendocrine Markers Associated with Pubertal Regulation in Female Rat Offspring.
Gumus M, Gunaydın-Turker B, Akgun-Unal N et al.
Int J Mol Sci·2026·Animal·PubMed →
Seminal Plasma Kisspeptin-1 and Kisspeptin-54 Levels Are Associated With Semen Parameters and Oxidative Stress in Male Infertility.
Korkmaz O, Karabulut S, Macit P
Clin Endocrinol (Oxf)·2026·Animal·PubMed →
Daily Rhythmic Changes in Kisspeptin Gene Expression and Testosterone Hormone in Male Syrian Hamsters (Mesocricetus auratus).
Balkan Eİ, Gündüz B
Zoolog Sci·2026·Animal·PubMed →
Positive actions of fibroblast growth factor 21 on female zebrafish reproductive axis.
Uju CN, Unniappan S
Theriogenology·2026·Animal·Liver Protection·PubMed →
Maternal-Neonatal Metabolic Continuity and Early Postnatal HPG Axis Activity in Healthy Term Neonates.
Koca M, Karaoglan M, Tepe NB et al.
Clin Endocrinol (Oxf)·2026·Animal·PubMed →
Kisspeptin Signaling Suppresses HRas(G12V)-induced Tumor Growth and Metastasis by Inhibiting SP1-dependent N-cadherin Expression in NIH3T3 Cells.
Hwang HH, Cho SG
Anticancer Res·2026·Animal·PubMed →
Role of KNDy neurons in the negative-feedback suppression of gonadotropin secretion in female rats.
Campideli-Santana AC, Silva KSC, Araujo-Lopes R et al.
Endocrinology·2026·Animal·Neuroprotection·PubMed →
A brain-first framework for perimenopause management: the case for non-invasive neuromodulation.
Radytė E, Karvelyte I
Front Glob Womens Health·2026·Animal·PubMed →
Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.
Sahin-Buyukkorkmaz L, Tasdemir S, Ozhan O et al.
Int Urol Nephrol·2026·Animal·PubMed →
Photoperiodic regulation of reproduction and hypothalamic-pituitary-gonadal axis in Phoxinus lagowskii adults.
Hu T, Zhou J, Guo B et al.
Fish Physiol Biochem·2026·Animal·PubMed →
Involvement of cocaine- and amphetamine-regulated transcript neurons in glucoprivic suppression of pulsatile luteinizing hormone secretion in female rats.
Matsuzaki S, Hazim S, Toyohama Y et al.
J Reprod Dev·2026·Animal·Neuroprotection·PubMed →
Comparison of the effects of atypical antipsychotics on decreased libido in zebrafish and their mechanisms.
Shinokawa K, Hattori S, Miyauchi M et al.
Behav Brain Res·2026·Animal·Sexual Health·PubMed →
The growth of developing oocytes and hypothalamus-pituitary-ovary functions in goldfish under absolute food deprivation.
Mirjalili V, Kazori N, Alavi SMH et al.
Am J Physiol Regul Integr Comp Physiol·2026·Animal·PubMed →
Kisspeptin.
Neves JR, Gonçalves J
Trends Endocrinol Metab·2026·Animal·PubMed →
Effects of Water Avoidance Stress as a Psychological Stress Model and Coenzyme Q10 on Reproductive, Endocrine, and Ovarian Responses in Adult Female Rats.
Yardimci A, Ertugrul T, Gokdere E et al.
Animals (Basel)·2026·Animal·PubMed →
Correction: IGF-1 supplementation improves in vitro maturation quality of Capra hircus oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling.
Widjiati W, Luqman EM, Darsini N et al.
Front Vet Sci·2026·Animal·PubMed →
The endogenous ghrelin antagonist, LEAP2, accelerates puberty onset in conditions of early obesity.
Torres-Granados C, Morris PG, Ruiz-Cruz M et al.
Metabolism·2026·Animal·Weight Loss, Neuroprotection·PubMed →
Dynamic Profiles of Serum Kisspeptin and Delta-Like 1 Homolog during Gonadotropin-Releasing Hormone Stimulation in Central Precocious Puberty and Premature Thelarche.
Paisansukanant K, Chatdamrongsakool K, Chotipakornkul N et al.
Neuroendocrinology·2026·Animal·PubMed →
Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome.
Wang X, Zou Z, Huang H
Neuropeptides·2026·Animal·PubMed →
Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes.
Su S, Ye Q, Chen F et al.
Placenta·2026·Animal·PubMed →
The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
Robert V, Lomet D, Dardente H et al.
Mol Cell Endocrinol·2026·Animal·PubMed →
Comparative Analysis of Kisspeptin Levels and KISS1 Gene Polymorphism in Patients with Polycystic Ovary Syndrome (PCOS): Correlation with the Luteinizing Hormone-Follicle-Stimulating Hormone Ratio and PCOS-Associated Variables.
Talukdar C, Choudhary SS, Talukdar PM et al.
Cureus·2025·Human·PubMed →
Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol.
Yang B, Zheng N, Shao Q et al.
BMC Nephrol·2025·Human·PubMed →