Research Index
CagriSema Research Index
PSI surfaces 50 peer-reviewed studies on CagriSema, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Serum kisspeptin levels in pregnant and non-pregnant diestrus bitches: a pilot study.
Coppola T, Barbato O, Menchetti L et al.
Front Vet Sci·2026·Human·PubMed →
First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report.
Uyanık G, Yüksel M, Kara F et al.
Vet Res Commun·2026·Human·PubMed →
Identification of a novel KISS1R (GPR54) gene variant (c.505+2T>G) in a patient with congenital hypogonadotropic hypogonadism: A case report and literature review.
Menekse B, Ucgul E, Bakir A et al.
Exp Ther Med·2026·Human·PubMed →
Effect of post-mating TAK-683 (Kisspeptin analog) treatment on luteal morphology and function in suckling goats with lactational anestrus.
Uyanık G, Yüksel M, Abay M et al.
Anim Reprod Sci·2026·Human·PubMed →
Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.
Galbiati F, Plessow F, Plummer L et al.
J Neuroendocrinol·2026·Human·PubMed →
Concentration-QTc Modeling to Support Clinical Development of Fezolinetant.
Nielsen JC, Saito M, Wang X et al.
Clin Pharmacol Drug Dev·2026·Human·PubMed →
Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.
Bozkurt G, Agaoglu AR, Aslan S et al.
Theriogenology·2026·Human·PubMed →
Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.
Puffer MS, Yang J, Esparza LA et al.
Endocrinology·2026·Animal·PubMed →
Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.
Krombholz S, Korsmeier L, Thomas A et al.
Drug Test Anal·2026·Animal·PubMed →
Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome.
Li X, He Y, Wang Y et al.
J Ovarian Res·2026·Animal·PubMed →
Knockout of PI4-Kinase A in GnRH Neurons Causes their Prepubertal Death.
Constantin S, Nessa N, Stojilkovic SS
bioRxiv·2026·Animal·PubMed →
Photoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats.
Shah H, Dan N, Salunke A et al.
Photochem Photobiol Sci·2026·Animal·PubMed →
A protocol for physiologic LH surge induction in gonad intact female mice.
Silva MSB, Talbi R, Torres E et al.
Endocrinology·2026·Animal·Neuroprotection·PubMed →
Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö et al.
Reprod Domest Anim·2026·Animal·PubMed →
Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.
Huang S, Chen Z, Gong W et al.
Neuropeptides·2026·Animal·PubMed →
Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
Szysiak N, Kosior-Korzecka U, Greguła-Kania M et al.
J Vet Res·2026·Animal·PubMed →
Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.
Suocheng W, Linglong X, Jingshuang G et al.
Mol Reprod Dev·2026·Animal·PubMed →
Kisspeptin-54 confers renal protection in diabetic nephropathy by ameliorating endothelial permeability through ZEB1 inhibition.
Gao L, Lv Q, Wang Y et al.
Tissue Cell·2026·Animal·PubMed →
Corrigendum to "Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway" [Free Radic Biol Med.171 (2021) 99-111].
Huang Y, Guo Y, Huang L et al.
Free Radic Biol Med·2026·Animal·PubMed →
GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice.
Eddleston T, Morris PG, Herbison AE
J Neuroendocrinol·2026·Animal·Neuroprotection·PubMed →
Molecular and functional characterization of the kisspeptin receptor Kissr3 in the large yellow croaker (Larimichthys crocea).
Yuan H, Huang B, Zhang R et al.
Comp Biochem Physiol B Biochem Mol Biol·2026·Animal·PubMed →
Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.
Morris PG, Liu X, Birt E et al.
Endocrinology·2026·Animal·Neuroprotection·PubMed →
The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals.
Ünlükal N, Aniç S, Dursunoğlu D et al.
Genes (Basel)·2026·Animal·PubMed →
Cadmium-Induced Neuroendocrine Alterations: Gene Expression of the Kisspeptin-GnRH Axis and Delayed Puberty in Male Rats.
Arteaga-Silva M, Cornejo de la Concha EM, Landero-Huerta DA et al.
Toxics·2026·Animal·PubMed →
Effects of Microplastics on the Central Reproductive Neuroendocrine System in a Sheep Model.
Młotkowska P, Osuch B, Marciniak E et al.
Int J Mol Sci·2026·Animal·PubMed →
Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.
Collado-Sole A, Borjini N, Zhai J et al.
Science·2026·Animal·PubMed →
Neuroendocrine effects of exogenous adropin administration on the hypothalamic pituitary testicular axis in male rats.
Eraslan E, Tanyeli A, Güler MC et al.
Turk J Med Sci·2026·Animal·PubMed →
Novel KISS1 Gene Mutation Leading to Male Hypogonadotropic Hypogonadism.
Wittner L, Mahindrakar S, Yasin A et al.
Exp Clin Endocrinol Diabetes·2026·Animal·PubMed →
Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue.
Lomet D, Robert V, Decourt C et al.
Animal·2026·Animal·PubMed →
Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
Santos BR, Dos Anjos Cordeiro JM, Santos LC et al.
Acta Physiol (Oxf)·2026·Animal·PubMed →
Investigation of Radiolabeled KISS1R Ligands as Promising Tools for Diagnosis and Treatment of Triple-Negative Breast Cancer.
Taş H, Schäfer M, Shuja-Uddin A et al.
Mol Pharm·2026·Animal·PubMed →
GPR54 regulates non-small cell lung cancer development via dopa decarboxylase.
Hwang HH, Lee SY, Lee C et al.
Signal Transduct Target Ther·2026·Animal·PubMed →
Targeting the NR5A1-KISS1R-EMT axis with a small-molecule inhibitor suppresses lung adenocarcinoma progression and metastasis.
Wang D, Hui K, Yuan C et al.
Cell Signal·2026·Animal·PubMed →
Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.
Khan S, Attaullah M, Zubair M et al.
Regul Toxicol Pharmacol·2026·Animal·PubMed →
In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells.
Miyake N, Suga H, Osuka S et al.
Reprod Biol Endocrinol·2026·Animal·PubMed →
Direct adverse effects of fipronil sulfone, diisopentyl phthalate and disperse red 60 on zebrafish hepatocytes.
Leite BA, de Oliveira DP, Unniappan S
Toxicol Rep·2026·Animal·PubMed →
Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice.
Starrett JR, Krasner D, Phillips CD et al.
bioRxiv·2026·Animal·PubMed →
Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.
Islam T, Yañez-Guerra LA, Semmens DC et al.
BMC Biol·2026·Animal·PubMed →
Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.
Delli V, Moulinier M, Lazaridou AM et al.
Nat Commun·2026·Animal·Neuroprotection·PubMed →
Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway.
Sun N, Sun P, Sun L et al.
PLoS One·2026·Animal·Glycemic Control·PubMed →
Tissue-Slice Organ-on-Chip Culture of Hypothalamic and Pituitary of Lambs─The Role of Phoenixin-20 as a Modulator of Gonadotrophic Axis.
Szlis M, Przybył BJ, Wójcik-Gładysz A
ACS Biomater Sci Eng·2026·Animal·PubMed →
KNDy neurons as an indirect target of insulin-like growth factor-1.
Silva JDN, de Sousa LMM, de Sousa ME et al.
J Neuroendocrinol·2026·Animal·GH Activity, Neuroprotection·PubMed →
Comparative Analysis of Kisspeptin Levels and KISS1 Gene Polymorphism in Patients with Polycystic Ovary Syndrome (PCOS): Correlation with the Luteinizing Hormone-Follicle-Stimulating Hormone Ratio and PCOS-Associated Variables.
Talukdar C, Choudhary SS, Talukdar PM et al.
Cureus·2025·Human·PubMed →
Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol.
Yang B, Zheng N, Shao Q et al.
BMC Nephrol·2025·Human·PubMed →
Evaluation and Treatment of Patients With Hypothalamic Hypogonadism.
Himel R, Keefe D
Obstet Gynecol Surv·2025·Human·PubMed →
High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary Hypogonadism.
Fang R, Carroll RS, Kaiser UB
bioRxiv·2025·Animal·PubMed →
Activity Changes of the Hypothalamus-Pituitary Hormonal Axis in Peripubertal Female Rats.
Jeon EY, Lee SH
Dev Reprod·2025·Animal·PubMed →
Evidence for KISS-1 nuclear translocation and PI3K/AKT signaling in the ultrastructurally and morphometrically analyzed human endometriosis.
Hamutoğlu R, Kaloğlu C, Bulut HE et al.
Front Cell Dev Biol·2025·Animal·PubMed →
Therapeutic Effects of Phytoestrogen Naringenin in Polycystic Ovary Syndrome (PCOS): Involvement of Kisspeptin and Calcitonin Gene Related Peptide Signalling Pathways.
Habibi M, Mahmoudi F, Haghighat K et al.
Rep Biochem Mol Biol·2025·Animal·PubMed →
Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.
Mo T, Qiu Y, He S et al.
J Ovarian Res·2025·Animal·PubMed →