Research Index
Setmelanotide Research Index
PSI surfaces 50 peer-reviewed studies on Setmelanotide, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Assays of Antifungal Activity of an Antimicrobial Peptide Against Botrytis cinerea.
Zhang M, Hu P, Jin H
Methods Mol Biol·2027·Animal·Antimicrobial·PubMed →
Species-specific tear proteomic signatures in humans and rabbits: A DIA mass spectrometry comparative study.
Kamalasanan S, Ahmed S, Clifton V et al.
Ocul Surf·2026·Human·PubMed →
A 16-Year-Old Male Patient With Severe Electrical Burns With Chronic and Recurrent Hospital-Acquired Opportunistic Infection With Carbapenem-Resistant Acinetobacter baumannii.
Hong J, Wang S, Du J et al.
Am J Case Rep·2026·Human·Antimicrobial·PubMed →
Effects of salivary proteinase 3 and oxidative stress markers on secondary caries following pit-and-fissure sealants in patients with S-ECC.
Xia S, Wang G
Ann Med Surg (Lond)·2026·Human·PubMed →
Hidden Mould in the Air: A Practical Narrative Mini-Review of Invasive Mould Infection Prevention for High-Risk Patients and Clinicians.
Bauer A, Lass-Flörl C, Steixner S et al.
Mycoses·2026·Human·PubMed →
Impact of total suspended solids on disinfection efficacy of peracetic acid against Salmonella javiana.
Akindolani OO, Afshari M, Dong T et al.
Poult Sci·2026·Animal·PubMed →
Ameliorative effects of resveratrol versus sulforaphane on muscular trichinellosis in mice: The role of SIRT1 and SLC7A11 expression.
Ibrahim ES, Maghawry AA, Shawky SA et al.
J Helminthol·2026·Animal·Anti-Inflammatory·PubMed →
Impact of cathelicidin cleavage by SpeB on Streptococcus pyogenes CovRS signaling.
Guerra S, Qu C, LaRock CN
bioRxiv·2026·Animal·PubMed →
Developmental exposure to environmentally relevant bisphenol A bis(diphenyl phosphate) impairs host defense and disrupts epidermal immune and barrier responses in Caenorhabditis elegans.
Zheng Y, Zhu J, Fu L et al.
Environ Res·2026·Animal·PubMed →
Sex-dependent effects of Wolbachia on antifungal immunity in Drosophila melanogaster.
Kryukov V, Kosman E, Ganina M et al.
Dev Comp Immunol·2026·Animal·PubMed →
Unveiling the antiviral mechanism of A4S7: a synthetic antimicrobial peptide targeting dengue and other mosquito-borne enveloped virus infections.
Lin TC, Lu JW, Liu CH et al.
Antiviral Res·2026·Animal·PubMed →
Virulent bacterial pathogens disassemble the epididymal amyloid matrix to evade host defense.
Myers C, Cornwall GA
Hum Reprod·2026·Animal·PubMed →
Immune boosting to combat Alzheimer's disease: Position statement.
Aaby P, Arnold SE, Benn CS et al.
J Alzheimers Dis·2026·Animal·PubMed →
Copper stress upregulates oxidative stress response, histidine production, and iron acquisition genes in Escherichia coli.
Ainelo H, Jõearu K, Ainelo A et al.
FEMS Microbes·2026·Animal·PubMed →
Dynamic γδ T-cell Receptor remodeling and antigen-induced T-cell IFN-γ responses after SARS-CoV-2 infection during pregnancy: insights for γδ T-cell immunotherapy.
Ke Y, Pan R, Li L et al.
Front Immunol·2026·Animal·Immune Modulation·PubMed →
Ferret Glandular Myoepithelial Cells Are Multipotent Airway Progenitors with a Secretory Lineage Bias.
Ma Y, Yu M, Kobayashi Y et al.
Am J Respir Cell Mol Biol·2026·Animal·PubMed →
Antifungal Potential of Peptide-Enriched Fractions Isolated from Capsicum frutescens Seeds Against Yeasts of the Genus Candida.
de Azevedo Dos Santos L, da Silva MS, Taveira GB et al.
Probiotics Antimicrob Proteins·2026·Animal·PubMed →
Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults.
Jensen JA, Skouboe MK, Gervais A et al.
J Exp Med·2026·Animal·PubMed →
Non-Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA.
Huang Y, Shen R, Huang X et al.
Adv Sci (Weinh)·2026·Animal·PubMed →
Artesunate Targets MBL2 to Modulate the TLR4/NRF2/HO‑1 Axis and Ameliorate Podophyllotoxin‑Induced Liver Injury.
Wei M, He J, Zhang Y et al.
Drug Des Devel Ther·2026·Animal·PubMed →
Antimicrobial peptide Pt5-1c exerts potent immunomodulatory and antiviral effects by facilitating cellular delivery of cGAMP.
Zhao X, Ding Z, Zhang J et al.
Front Immunol·2026·Animal·Antimicrobial, Immune Modulation·PubMed →
Stage-Adaptive Polymeric Platforms: Design of an Alginate/CMC Hydrogel Co-Loaded With Silver Nanoparticles and α-Pinene-Rich Essential Oil for Wound Regeneration.
Kakaei N, Ahmadi A, Naseri V et al.
J Biomed Mater Res B Appl Biomater·2026·Animal·Wound Healing, Antimicrobial·PubMed →
Comparative Genomics of the Enterobacter cloacae Mobilome: Prophage Diversity and Anti-Phage Defense Systems in Phage Satellites.
Alrafaie A, Alqurainy N
Viruses·2026·Animal·PubMed →
Combined HMOs and α-MFGM Ameliorate LPS-Induced Intestinal Mucosal and Systemic Immune Dysfunction via Modulation of Gut Microbiota.
Wu J, Shi Z, Li J et al.
Nutrients·2026·Animal·GI Protection, Anti-Inflammatory·PubMed →
Antibiotic Selection for Sustained Local Therapy May Be Important to Reduce Pseudomonas aeruginosa Dominance Against Staphylococcus aureus and Bone Response Modulation in an Ovine Polymicrobial Fracture-Related Infection Model.
Williams D, Falconer R, Rothberg D et al.
Microorganisms·2026·Animal·PubMed →
A Pilot Proteomics Analysis of Mycobacterium tuberculosis Lacking a Putative Short-Chain Dehydrogenase Rv0148.
Bhargavi G, Deenadayalan A, Palaniyandi K et al.
Int J Mol Sci·2026·Animal·PubMed →
Antifungal Efficacy of Carbon Quantum Dots Combined with Photodynamic Therapy Against Alternaria alternata.
Ni ZJ, Yang RT, Ma RH et al.
Foods·2026·Animal·PubMed →
Molecular Cloning and Functional Analysis of Lumbricin in Urechis unicinctus.
Sun X, Sun L, Fan M et al.
Biology (Basel)·2026·Animal·PubMed →
Analytical and Clinical Evaluation of a Fully Automated Direct-from-Whole-Blood Multiplex PCR Assay Using Large-Volume Reverse Elution for Rapid Bloodstream Infection Diagnosis.
Tai CS, Chung HY, Lin TH et al.
Antibiotics (Basel)·2026·Animal·PubMed →
Adaptive Response of Escherichia coli to Pexiganan: Insights from Genomic Analysis.
Can Kurt K, Katzin LF, Tamaddon L et al.
Antibiotics (Basel)·2026·Animal·PubMed →
Cucumber Mosaic Virus Promotes Sphingolipid Biosynthesis to Alleviate Host Unfolded Protein Response (UPR)-Mediated Immunity.
Yao J, Wu S, Gao S et al.
Mol Plant Pathol·2026·Animal·PubMed →
Mechanisms underlying host-specific horizontal transfer of shrimp AHPND virulence plasmid: Vibrio immunity and colonization environment.
Chen R, Yan Y, Yan S et al.
J Invertebr Pathol·2026·Animal·PubMed →
High glucose with insulin signalling blockade promotes cholesterol-sensitive, FAK-dependent UPEC invasion and blunts bladder antimicrobial defence.
Maurya S, Monika, Thapa J et al.
Biochem Biophys Res Commun·2026·Animal·PubMed →
Targeted lysosomal activation in bladder epithelium enhances clearance of intracellular uropathogenic Escherichia coli.
Tomasek K, Skurvydaite K, Paduthol G et al.
PLoS Pathog·2026·Animal·Antimicrobial·PubMed →
Ethanol exposure is associated with spatial and taxon-specific gut microbiota remodeling characterized by ecological adaptation rather than broad activation of microbial ethanol metabolism.
Li M, Mao J, Liu S et al.
Gut Microbes·2026·Animal·PubMed →
Fibrin-rich environment drives catheter-associated UTIs by suppressing macrophage defenses.
Marrufo AM, Gager C, Molina JJ et al.
Nat Commun·2026·Animal·Antimicrobial·PubMed →
Steric Control of Competitive Versus Noncompetitive Lactoperoxidase Inhibition by Amide-Linked Iridium(III) Complexes.
Kırboğa KK, Sağır F, Köksal Z et al.
Arch Pharm (Weinheim)·2026·Animal·PubMed →
A Modular Fusion Protein Strategy Confers Broad-Spectrum Resistance Against Phytophthora infestans, Alternaria solani, and Ralstonia solanacearum.
Yang K, Wang R, Liu L et al.
J Fungi (Basel)·2026·Animal·PubMed →
Identification of Novel AChE-Targeting Neuroprotective Peptides from Pacific Oyster (Crassostrea gigas): An Integrated Pipeline of Peptidomics, Molecular Dynamics, and Cellular Validation.
Suo SK, Dang K, Zhang YY et al.
Mar Drugs·2026·Animal·Neuroprotection·PubMed →
Crosstalk Between BmToll9-2, the Toll Pathway, and Antimicrobial Peptides in the Silkworm (Bombyx mori) Larval Fat Body.
Lin R, Li S, Lv H et al.
Insects·2026·Animal·PubMed →
Development of Antimicrobial Coatings by Incorporating Curcumin and Silver-Based Additive into a Commercial Water-Based Paint.
Pescosolido F, Vesco S, Carotenuto F et al.
Biomimetics (Basel)·2026·Animal·PubMed →
Gut archaea drive human MAIT cell responses.
Fisher-Pearson N, Lett MJ, Maylam IWD et al.
bioRxiv·2026·Animal·PubMed →
IFN-γ protects the human blood-brain barrier from Toxoplasma gondii-mediated dysfunction via CCL2 suppression.
Somenzi MC, Bell KT, Bitters AM et al.
J Neuroinflammation·2026·Animal·PubMed →
Bacterial Contribution to Hydrogen Peroxide Decomposition in Lake Erie Cyanobacterial Harmful Algal Bloom Communities Is Dependent on Bloom Stage.
Donovan CE, Padilla G, Ashbaugh M et al.
Environ Microbiol Rep·2026·Animal·PubMed →
SARD1 and CBP60g redundantly regulate N-hydroxypipecolic acid- and salicylic acid-dependent systemic immunity but are dispensable for the activation of indolic defense metabolism.
Perrar M, Gross M, Petzsch P et al.
Plant J·2026·Animal·PubMed →
Genome-wide characterization of the JrCHI family and functional validation of JrCHI6 and JrCHI24 conferring resistance to Alternaria tenuissima in walnut.
Li T, Chen W, Wang B et al.
BMC Plant Biol·2026·Animal·PubMed →
Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma.
Tian T, Xue Y, Sun C et al.
Nat Commun·2026·Animal·Liver Protection·PubMed →
Molecular and Functional characterization of a novel C-type lectin during WSSV infection in Eriocheir sinensis.
Huang Y, Qin H, Wu X et al.
J Invertebr Pathol·2026·Animal·PubMed →
Perfluorooctane sulfonate directly interacts with IRF3 to attenuate antiviral innate immunity.
Liang Q, Li Y, Sun Z et al.
Proc Natl Acad Sci U S A·2026·Animal·Immune Modulation·PubMed →
The 3R-MYB transcription factor VvMYB3R5 regulates Colletotrichum viniferum resistance through affecting proanthocyanidin synthesis in grapevine.
Zhao T, Li N, Huang S et al.
Plant Physiol·2026·Animal·PubMed →