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INDEXED STUDIES

Retatrutide — Indexed Studies

50 most recent studies indexed by PSI from PubMed and clinical databases

Showing 50 of 50 studies

Perceived benefits of treatment for obesity with retatrutide: A qualitative study of patients in a phase 2 clinical trial.

Goetz IA, Kanu C, Hoover A et al.

Obes Pillars(2025)
Human
PubMed

Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in Patients with Chronic Kidney Disease.

Heerspink HJL, van Raalte DH, Bjornstad P et al.

Nephrol Dial Transplant(2025)
Human
PubMed

Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.

Kanu C, Boye KS, Poon JL et al.

Diabetes Obes Metab(2025)
Human
Glycemic ControlAppetite RegulationWeight Loss
PubMed

Association between patient-reported eating behaviours and weight change: Secondary analyses of a randomized, double-blind trial comparing retatrutide and placebo in people with obesity or overweight.

Kanu C, Wu Q, Poon JL et al.

Diabetes Obes Metab(2025)
Human
PubMed

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids.

Wen Y, Lemen D, Lin Y et al.

Diabetes Obes Metab(2025)
Human
Glycemic Control
PubMed

The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity.

Heerspink HJL, Lu Z, Du Y et al.

Kidney Int Rep(2025)
Human
PubMed

Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.

Coskun T, Wu Q, Schloot NC et al.

Lancet Diabetes Endocrinol(2025)
Human
Glycemic Control
PubMed

Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials.

Guo H, Yang J, Huang J et al.

Obes Pillars(2025)
Human
PubMed

Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials.

Xie Z, Zheng G, Liang Z et al.

Metabolism(2024)
Human
Weight Loss
PubMed

Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.

Sanyal AJ, Kaplan LM, Frias JP et al.

Nat Med(2024)
Human
Liver Fat (MASLD)Liver ProtectionWeight Loss
PubMed

Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.

Rosenstock J, Frias J, Jastreboff AM et al.

Lancet(2023)
Human
PubMed

Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.

Jastreboff AM, Kaplan LM, Frías JP et al.

N Engl J Med(2023)
Human
PubMed

Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models.

Briand F, Le Cudennec C, Grasset E et al.

Obesity (Silver Spring)(2026)
Animal
PubMed

Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison.

Hitaka K, Sugawara T, Matsumoto M et al.

Int J Obes (Lond)(2026)
Animal
PubMed

Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis.

Chan ZH, Omar AS, Gill K et al.

Cardiol Rev(2026)
Animal
PubMed

Development of the Weight and Emotions Scale (WES).

Kanu C, Kimel M, Goetz I et al.

Obes Sci Pract(2026)
Animal
PubMed

[Nephrology : what's new in 2025].

Nanchen G, Pruijm M, Lamine F et al.

Rev Med Suisse(2026)
Animal
Glycemic Control
PubMed

Engineered nutrient-stimulated hormonal multi-agonists for precision targeting of obesity and metabolic disorders.

Cho YK, Jung CH

Clin Mol Hepatol(2025)
Animal
PubMed

Development and Content Evaluation of the Eating Behavior and Appetite Questionnaire (EBAQ) for Individuals with Obesity.

Kanu C, Clucas C, Skalicky A et al.

Adv Ther(2026)
Animal
Weight LossAppetite Regulation
PubMed

Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials.

Giblin K, Kaplan LM, Somers VK et al.

Diabetes Obes Metab(2026)
Animal
OsteoarthritisSleep ApneaWeight Loss
PubMed

Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge.

Viebahn GK, Khurana A, Freund L et al.

Am J Physiol Gastrointest Liver Physiol(2025)
Animal
Liver ProtectionLiver Fat (MASLD)
PubMed

Strategic Design of Triple GLP-1R/GCGR/GIPR Agonists with Varied Receptor Potency: Achieving Comparable Glycemic and Weight Reduction Effects.

Wang S, Liu Y, Yan Z et al.

J Med Chem(2025)
Animal
Weight LossGlycemic Control
PubMed

Effect of Incretin-Based Therapies on Blood Pressure: A Systematic Review and Meta-Analysis.

Basile C, Merolla A, Mancusi C et al.

Eur J Prev Cardiol(2025)
Animal
PubMed

Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats.

Windram M, Lovelock DF, Carew JM et al.

Psychopharmacology (Berl)(2025)
Animal
PubMed

Inotropic effects of retatrutide in isolated human atrial preparations.

Neumann J, Ahlrep U, Hofmann B et al.

Naunyn Schmiedebergs Arch Pharmacol(2026)
Animal
PubMed

Contractile effects of retatrutide in isolated mouse atrial preparations.

Neumann J, Ahlrep U, Hofmann B et al.

Naunyn Schmiedebergs Arch Pharmacol(2025)
Animal
PubMed

Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression.

Marathe SJ, Grey EW, Bohm MS et al.

NPJ Metab Health Dis(2025)
Animal
PubMed

Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.

Cui X, Zhu Y, Zeng L et al.

Adv Sci (Weinh)(2025)
Animal
Weight Loss
PubMed

Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.

DiStefano MJ, Dardouri M, Moore GD et al.

J Pharm Policy Pract(2025)
Animal
PubMed

The First Triple Agonist for Antiobesity: Retatrutide.

Tetelbaun L, Mullally JA, Frishman WH

Cardiol Rev(2024)
Animal
PubMed

The "Weight" for a New Agent Is Almost Over: A Commentary on the Novel Triagonist Retatrutide for Obesity.

Deravi M, Piszczatoski C, Phillips B et al.

J Pharm Technol(2024)
Animal
PubMed

Retatrutide.

Ramsbacher N

Clin Diabetes(2024)
Animal
PubMed

Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.

Ma J, Hu X, Zhang W et al.

Endocrine(2025)
Animal
Glycemic Control
PubMed

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.

Li W, Zhou Q, Cong Z et al.

Cell Discov(2024)
Animal
PubMed

Unleashing the power of retatrutide: A possible triumph over obesity and overweight: A correspondence.

Naeem M, Imran L, Banatwala UESS

Health Sci Rep(2024)
Animal
PubMed

Recent advances in peptide-based therapies for obesity and type 2 diabetes.

Bailey CJ, Flatt PR, Conlon JM

Peptides(2024)
Animal
Glycemic ControlWeight Loss
PubMed

Peptide Polyagonists for the Treatment of Nonalcoholic Fatty Liver Disease.

Polyzos SA, Frühbeck G, Kiortsis DN

Curr Pharm Des(2023)
Animal
Liver Fat (MASLD)Glycemic Control
PubMed

At ObesityWeek, More Data and Questions About Semaglutide, Tirzepatide, and Retatrutide.

Ruder K

JAMA(2024)
Animal
Glycemic ControlWeight Loss
PubMed

Can small molecule GLP-1 agonists be the next first-line drugs in type-2 diabetes mellitus?

Seetharaman R, Pandit S

J Basic Clin Physiol Pharmacol(2024)
Animal
Glycemic Control
PubMed

Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond.

Tsilingiris D, Kokkinos A

Metabolism(2024)
Animal
Glycemic ControlWeight LossLiver Fat (MASLD)
PubMed

Retatrutide: a triple incretin receptor agonist for obesity management.

Ray A

Expert Opin Investig Drugs(2023)
Animal
Glycemic ControlWeight Loss
PubMed

Triple-Hormone-Receptor Agonist Retatrutide for Obesity. Reply.

Jastreboff AM, Kaplan LM, Hartman ML

N Engl J Med(2023)
Animal
Weight Loss
PubMed

Triple-Hormone-Receptor Agonist Retatrutide for Obesity.

Elfeki MA, Alkhouri N

N Engl J Med(2023)
Animal
PubMed

Triple-Hormone-Receptor Agonist Retatrutide for Obesity.

Bisson A, Fauchier G, Fauchier L

N Engl J Med(2023)
Animal
PubMed

Breaking the mold: revolutionary new obesity drugs set to transform treatment landscape?

Seetharaman R, Pandit S

J Basic Clin Physiol Pharmacol(2023)
Animal
Weight LossGlycemic Control
PubMed

Triple-Hormone Combination Retatrutide Induces 24% Body Weight Loss.

Harris E

JAMA(2023)
Animal
Weight Loss
PubMed

A new class of glucose-lowering therapy for type 2 diabetes: the latest development in the incretin arena.

Bain SC, Min T

Lancet(2023)
Animal
Glycemic Control
PubMed

Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective.

Sidik S

Nature(2023)
Animal
Weight Loss
PubMed

The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying.

Urva S, O'Farrell L, Du Y et al.

Diabetes Obes Metab(2023)
Animal
Glycemic Control
PubMed

Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity?

Doggrell SA

Expert Opin Investig Drugs(2023)
Animal
Glycemic ControlWeight Loss
PubMed
Back to Retatrutide Research Overview

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