Research Index
MOTS-c Research Index
PSI surfaces 50 peer-reviewed studies on MOTS-c, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Li H, Zhang Y, Jian Y et al.
Bioact Mater·2027·Animal·PubMed →
MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.
Musolino M, Roumeliotis A, Roumeliotis S et al.
Int Urol Nephrol·2026·Human·PubMed →
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Suliman ME, Rahman A, Qureshi AR et al.
Antioxidants (Basel)·2026·Animal·PubMed →
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
Rice MC, Imun M, Jung SW et al.
Elife·2026·Animal·PubMed →
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.
Xing L, Lu B, Zhu X et al.
Inflamm Regen·2026·Animal·PubMed →
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.
Mills AR, de Souza A, Pham T et al.
Exp Physiol·2026·Animal·Glycemic Control, Anti-Inflammatory·PubMed →
Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study.
Sonay HO, Duran EN, Algemi M et al.
J Clin Med·2026·Animal·PubMed →
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.
Jamnick NA, Livingston PD, Gammon CJ et al.
Front Med (Lausanne)·2026·Animal·PubMed →
MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury.
Santhanam SS, Jayaraman S, Rajesh SS et al.
Mol Biol Rep·2026·Animal·PubMed →
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Liao Y, Xu J, Jiao Y et al.
Biomedicines·2026·Animal·PubMed →
Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.
Sączek A, Batko K, Banaszkiewicz M et al.
Kidney Blood Press Res·2026·Animal·Cardiovascular Risk·PubMed →
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.
Shi J, Wu Y, Liu X et al.
Autophagy·2026·Animal·PubMed →
LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection.
Zhang YL, Huang G, Li SP et al.
Redox Biol·2026·Animal·PubMed →
MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.
Li SH, Chen SQ, Lu T et al.
Life Sci·2026·Animal·PubMed →
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
Filibeli BE, Dedemoglu F, Garipçin P et al.
Arch Endocrinol Metab·2026·Animal·PubMed →
Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.
Liu S, Ru K, Shen YJ et al.
Free Radic Biol Med·2026·Animal·PubMed →
MOTS-c primes adrenal cortex metabolism without directly driving steroidogenesis.
Blatkiewicz M, Kaminski K, Sobalska-Kwapis M et al.
Folia Histochem Cytobiol·2026·Animal·PubMed →
Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.
Kotan GC, Bayraktar B
BMC Vet Res·2026·Animal·PubMed →
Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.
Chen D, Zhou MH, Zhu WY et al.
Eur J Pharmacol·2026·Animal·Tissue Remodeling·PubMed →
MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway.
Li N, Xu Y, Chen Q et al.
Protein Pept Lett·2026·Animal·Liver Protection·PubMed →
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Elhusseiny R, Ihsan M, Bellefroid T et al.
Physiol Rep·2026·Animal·PubMed →
Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway.
Li Z, Wang T, Fu Y et al.
Front Endocrinol (Lausanne)·2026·Animal·PubMed →
Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor.
Güvenir Seven S, Sahin H, Erkanlı Şentürk G et al.
Mol Neurobiol·2026·Animal·PubMed →
Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
Kutuk IS, Akin S, Demirel H et al.
Sci Rep·2026·Animal·PubMed →
MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy.
Feng Z, Xing Y, Lou J et al.
Free Radic Biol Med·2026·Animal·PubMed →
Exogenous MOTS-c mitigates myocardial ischemia-reperfusion injury: experimental and in silico evidence from rat heart models.
Santhanam SS, Jayaraman S, Kurian GA
Naunyn Schmiedebergs Arch Pharmacol·2026·Animal·PubMed →
Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss.
Yoon SH, Yuan F, Zhu X et al.
J Clin Transl Endocrinol·2026·Animal·PubMed →
MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
Gudiksen A, Hansen CC, van der Stede T et al.
Free Radic Biol Med·2026·Animal·Muscle Recovery·PubMed →
Muscle-Targeted Nanocomposite Therapy Alleviates Age-Related Sarcopenia via Antioxidant and Metabolic Reprogramming.
Liu Z, Shen Z, Lu H et al.
ACS Nano·2026·Animal·Muscle Recovery, Longevity·PubMed →
MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.
Chen D, Zhao HM, Sun XL et al.
Int J Mol Med·2026·Animal·PubMed →
Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.
Elhusseiny R, Ihsan M, Labidi M et al.
Med Sci Sports Exerc·2025·Human·Muscle Recovery·PubMed →
Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.
Luo Z, Ji R, Ye R et al.
Sleep Biol Rhythms·2025·Human·PubMed →
Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement.
Sánchez-Quintero MJ, Iboleón A, Martín Chaves L et al.
Biologics·2025·Human·PubMed →
Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes.
Ikonomidis I, Pavlidis G, Pliouta L et al.
J Am Heart Assoc·2025·Human·Glycemic Control·PubMed →
MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study.
Zicarelli M, Greco M, Roumeliotis S et al.
Medicina (Kaunas)·2025·Human·PubMed →
Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids.
Mohtashami Z, Schneider K, Azimi R et al.
Hum Cell·2025·Human·PubMed →
Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.
Erol V, Avci E, Kabukcu Hacioglu S et al.
Cureus·2025·Animal·PubMed →
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
Rodríguez-Esparragón F, Cazorla-Rivero SE, Torrealba E et al.
Int J Mol Sci·2025·Animal·Longevity·PubMed →
Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure.
Asil H, Demiryürek AT, Düzen IV et al.
Eur J Pharmacol·2024·Human·Glycemic Control·PubMed →
The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study.
Bolignano D, Greco M, Presta P et al.
Blood Purif·2024·Human·Cardiovascular Risk·PubMed →
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
Kavak AG, Karslioglu I, Saracaloglu A et al.
Curr Radiopharm·2024·Human·PubMed →
The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease.
Kirik A, Dogru T, Yanik B et al.
Eur Rev Med Pharmacol Sci·2023·Human·Liver Fat (MASLD), Metabolic Syndrome·PubMed →
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
Saracaloglu A, Mete AÖ, Ucar DF et al.
Curr Protein Pept Sci·2023·Human·PubMed →
Serum MOTS-c levels remain unchanged in patients with preeclampsia.
Tok A, Serdar O, Kandilcik OF et al.
Ginekol Pol·2023·Human·PubMed →
Circulating levels of MOTS-c in patients with breast cancer treated with metformin.
Cuyàs E, Verdura S, Martin-Castillo B et al.
Aging (Albany NY)·2022·Human·PubMed →
MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease.
Yaşar E, Çakmak T, Bayramoğlu A et al.
Eur Rev Med Pharmacol Sci·2022·Human·Cardiovascular Risk·PubMed →
Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.
Dieli-Conwright CM, Sami N, Norris MK et al.
Sci Rep·2021·Human·PubMed →
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
von Walden F, Fernandez-Gonzalo R, Norrbom J et al.
J Appl Physiol (1985)·2021·Human·Muscle Recovery·PubMed →
β-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease.
Ikonomidis I, Katogiannis K, Kyriakou E et al.
J Thromb Thrombolysis·2020·Human·Glycemic Control·PubMed →
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
Raijmakers RPH, Jansen AFM, Keijmel SP et al.
J Transl Med·2019·Human·PubMed →