MK-677 (Ibutamoren) Research Index

Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review.

Jaffry K, Shah J, Naqash N

Cureus·2026·Human·PubMed →

Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding.

Tojo R, Tashiro M, Takahashi H et al.

Neurosci Res·2026·Animal·Anxiety & Mood·PubMed →

Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.

Kintz P, Gheddar L

Clin Chim Acta·2026·Animal·PubMed →

Hepatotoxicity induced by MK-677.

Cobani E, Amin MS, Hasso M et al.

BMJ Case Rep·2025·Animal·PubMed →

SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON.

Barrios MM, Deconinck E, Vanhee C et al.

Drug Test Anal·2025·Animal·PubMed →

Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency.

Xu H, Liu M, Jia X et al.

J Med Chem·2025·Animal·GH Activity·PubMed →

Investigating the P53-dependent anti-cancer effect of ibutamoren in human cancer cell lines.

Abdul Ghafoor N, Rasuli S, Tanriverdi Ö et al.

Basic Clin Pharmacol Toxicol·2025·Animal·PubMed →

Reversible Gynecomastia and Hypogonadism Due to Usage of Commercial Performance-Enhancing Supplement Use.

Chong S, Woolnough CA, Koyyalamudi SR et al.

JCEM Case Rep·2024·Animal·PubMed →

Detection of the growth hormone secretagogue MK-0677 in equine hair following oral administration.

Viljanto M, Cutler C, Taylor P et al.

Drug Test Anal·2023·Animal·GH Activity·PubMed →

Skin Acceleration Levels Estimated by a Neck-surface Accelerometer during Phonation Are Affected by The Mechanical Properties of The Anterior Cervical Skin.

Umatani M, Ogawa M, Hosokawa K et al.

J Voice·2023·Animal·PubMed →

LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report.

Cardaci TD, Machek SB, Wilburn DT et al.

Exp Physiol·2022·Human·Muscle Recovery·PubMed →

A GH Secretagogue Receptor Agonist (LUM-201) Elicits Greater GH Responses than Standard GH Secretagogues in Subjects of a Pediatric GH Deficiency Trial.

Bright GM, Thorner MO

Horm Res Paediatr·2022·Human·GH Activity·PubMed →

Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control.

Philip M, Karakka Kal AK, Subhahar MB et al.

Rapid Commun Mass Spectrom·2022·Animal·GH Activity·PubMed →

Equine metabolism of the growth hormone secretagogue MK-0677 in vitro and in urine and plasma following oral administration.

Cutler C, Viljanto M, Taylor P et al.

Drug Test Anal·2022·Animal·GH Activity·PubMed →

Neural networks for computing and denoising the continuous nonlinear Fourier spectrum in focusing nonlinear Schrödinger equation.

Sedov EV, Freire PJ, Seredin VV et al.

Sci Rep·2021·Animal·PubMed →

Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair.

Gheddar L, Raul JS, Kintz P

J Chromatogr B Analyt Technol Biomed Life Sci·2021·Animal·PubMed →

Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren.

Liu H, Sun D, Myasnikov A et al.

Nat Commun·2021·Animal·PubMed →

Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren.

Philip M, Karakka Kal AK, Subhahar MB et al.

Rapid Commun Mass Spectrom·2021·Animal·PubMed →

Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca(2+) Signaling in the Cortical Neurons In Vitro.

Turovsky EA, Turovskaya MV, Fedotova EI et al.

Int J Mol Sci·2021·Animal·PubMed →

Development and validation of liquid chromatography-tandem mass spectrometry method for screening six selective androgen receptor modulators in dietary supplements.

Lee JH, Han JH, Jung EJ et al.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess·2021·Animal·PubMed →

An in vitro assay approach to investigate the potential impact of different doping agents on the steroid profile.

Piper T, Heimbach S, Adamczewski M et al.

Drug Test Anal·2021·Animal·PubMed →

Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.

Sales da Silva E, Ferreira PM, Castro CH et al.

Mol Cell Endocrinol·2020·Animal·PubMed →

Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles.

Yoon YS, Jang Y, Hoenen T et al.

BMB Rep·2020·Animal·PubMed →

MK0677, a Ghrelin Mimetic, Improves Neurogenesis but Fails to Prevent Hippocampal Lesions in a Mouse Model of Alzheimer's Disease Pathology.

Tian J, Wang T, Wang Q et al.

J Alzheimers Dis·2019·Animal·PubMed →

Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study.

Campbell GA, Patrie JT, Gaylinn BD et al.

Nephrol Dial Transplant·2018·Human·GH Activity·PubMed →

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.

Lee J, Kwon A, Chae HW et al.

Yonsei Med J·2018·Animal·GH Activity·PubMed →

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.

Jeong YO, Shin SJ, Park JY et al.

Int J Mol Sci·2018·Animal·Neuroprotection·PubMed →

Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet.

Van Wagoner RM, Eichner A, Bhasin S et al.

JAMA·2017·Animal·PubMed →

Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.

Harmatz ES, Stone L, Lim SH et al.

Biol Psychiatry·2017·Animal·Cognitive Enhancement, Anxiety & Mood·PubMed →

MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.

Adunsky A, Chandler J, Heyden N et al.

Arch Gerontol Geriatr·2011·Human·PubMed →

Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial.

Sevigny JJ, Ryan JM, van Dyck CH et al.

Neurology·2008·Human·GH Activity·PubMed →

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.

Nass R, Pezzoli SS, Oliveri MC et al.

Ann Intern Med·2008·Human·PubMed →

Summaries for patients. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults.

Ann Intern Med·2008·Human·PubMed →

Impurity profile tracking for active pharmaceutical ingredients: case reports.

Zhou L, Mao B, Reamer R et al.

J Pharm Biomed Anal·2007·Human·GH Activity·PubMed →

The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture.

Bach MA, Rockwood K, Zetterberg C et al.

J Am Geriatr Soc·2004·Human·GH Activity·PubMed →

The effect of treatment with the oral growth hormone (GH) secretagogue MK-677 on GH isoforms.

Svensson J, Boguszewski CL, Shibata F et al.

Growth Horm IGF Res·2003·Human·Weight Loss, GH Activity·PubMed →

Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.

Codner E, Cassorla F, Tiulpakov AN et al.

Clin Pharmacol Ther·2001·Human·GH Activity·PubMed →

Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.

Murphy MG, Weiss S, McClung M et al.

J Clin Endocrinol Metab·2001·Human·Bone Healing, Tissue Remodeling, GH Activity·PubMed →

Endocrine and non-endocrine activities of growth hormone secretagogues in humans.

Ghigo E, Arvat E, Broglio F et al.

Horm Res·1999·Human·GH Activity·PubMed →

Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677.

Svensson J, Carlsson B, Carlsson LM et al.

Clin Endocrinol (Oxf)·1999·Human·GH Activity, Weight Loss·PubMed →

Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.

Murphy MG, Bach MA, Plotkin D et al.

J Bone Miner Res·1999·Human·Bone Healing, Tissue Remodeling, GH Activity·PubMed →

Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a).

Svensson J, Jansson JO, Ottosson M et al.

J Clin Endocrinol Metab·1999·Human·Weight Loss, GH Activity·PubMed →

Growth hormone secretagogues: mechanism of action and use in aging.

Fuh VL, Bach MA

Growth Horm IGF Res·1998·Human·Longevity, GH Activity·PubMed →

Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.

Svensson J, Ohlsson C, Jansson JO et al.

J Bone Miner Res·1998·Human·Tissue Remodeling, Weight Loss·PubMed →

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.

Svensson J, Lönn L, Jansson JO et al.

J Clin Endocrinol Metab·1998·Human·Weight Loss, GH Activity·PubMed →

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.

Murphy MG, Plunkett LM, Gertz BJ et al.

J Clin Endocrinol Metab·1998·Human·GH Activity·PubMed →

Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.

Copinschi G, Leproult R, Van Onderbergen A et al.

Neuroendocrinology·1997·Human·GH Activity, Sleep·PubMed →

Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.

Chapman IM, Pescovitz OH, Murphy G et al.

J Clin Endocrinol Metab·1997·Human·Glycemic Control, GH Activity·PubMed →

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

Chapman IM, Bach MA, Van Cauter E et al.

J Clin Endocrinol Metab·1996·Human·Glycemic Control, GH Activity·PubMed →

Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

Copinschi G, Van Onderbergen A, L'Hermite-Balériaux M et al.

J Clin Endocrinol Metab·1996·Human·PubMed →