Research Index
LL-37 Research Index
PSI surfaces 50 peer-reviewed studies on LL-37, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study.
Yamaguchi T, Hosokawa K, Mineta T et al.
PLoS One·2026·Human·Sleep Apnea·PubMed →
[Evaluation of Serum LL-37 Levels in Patients with Brucellosis and Their Relationship with Clinical Course].
Gögebakan K, Özkurt Z, Öztürk N
Mikrobiyol Bul·2026·Human·PubMed →
Effects of tildrakizumab on circulating T cells in autoreactive psoriatic patients.
Facheris P, Favaro R, Valenti M et al.
Front Immunol·2026·Human·Immune Modulation, Anti-Inflammatory·PubMed →
Within-host adaptation mutations associated with persistent colonization of Pseudomonas aeruginosa in a silicosis patient.
Zhang F, Qian L, Yan Y et al.
Front Cell Infect Microbiol·2026·Human·Antimicrobial·PubMed →
Impact of cathelicidin cleavage by SpeB on Streptococcus pyogenes CovRS signaling.
Guerra S, Qu C, LaRock CN
bioRxiv·2026·Animal·PubMed →
Membrane Disruption and Charge Neutralization Drive Synergy Between LL37-Derived Peptides and Polymyxins Against E. coli.
Han W, Watkins NJ, Camesano TA
Biomolecules·2026·Animal·Antimicrobial, Tissue Remodeling·PubMed →
Calcitonin gene-related peptide promotes mast cell-mediated neuroimmune inflammation through the CALCRL/RAMP1-JAK3-STAT1 axis in rosacea.
Li X, Fan H, Sun R et al.
Front Immunol·2026·Animal·Anti-Inflammatory, Wound Healing·PubMed →
Coordination chemistry and antimicrobial activity of LL-37, its C-terminal fragment, and a peptidomimetic analogue.
Szarszoń K, Luszawska M, Jewgiński M et al.
Dalton Trans·2026·Animal·Antimicrobial·PubMed →
Combinatorial therapy of LL-37 and ADSCs accelerates diabetic wound repair by orchestrating NRROS-mediated crosstalk between TGF-β/SMAD and hippo/TEAD1 axes.
Wei L, Wang L, Zhong F et al.
Cytokine·2026·Animal·Wound Healing, Tissue Remodeling·PubMed →
Virtual screening identifies specnuezhenide as a potential therapeutic agent for rosacea via KLK5/TLR4/NF-κB pathway inhibition and metabolic modulation.
Xu J, Li X, Chen M et al.
Front Immunol·2026·Animal·Anti-Inflammatory, Wound Healing·PubMed →
Human neuronal cells SH-SY5Y as an in vitro model to study Neospora caninum infection and innate immune modulation.
Plá N, Burucúa MM, Moore DP et al.
Vet J·2026·Animal·Immune Modulation, Neuroprotection·PubMed →
A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions.
He YM, Lin T, Mu LX et al.
Zool Res·2026·Animal·Antimicrobial·PubMed →
Immunomodulatory Effects of Poly-D,L-Lactic Acid on LL-37-Driven Rosacea-like Inflammation via Suppression of mTORC1 Signaling.
Byun KA, Park JY, Oh S et al.
Int J Mol Sci·2026·Animal·Anti-Inflammatory·PubMed →
RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics.
Rayan B, Barnea E, Indig R et al.
Elife·2026·Animal·PubMed →
Interfacial activity and membrane interaction of Duttaphrynus melanostictus cathelicidin.
Francis F, Verma SS, Hans A et al.
Arch Biochem Biophys·2026·Animal·PubMed →
NF-κB/AP-1-mediated expression of the porcine cathelicidin proPMAP-37 suppresses inflammation by neutralizing LPS and inhibiting M1 macrophage polarization.
Fu Q, Xie K, Yu B et al.
BMC Vet Res·2026·Animal·PubMed →
Functional diversity of cathelicidin peptides in the frog lung: An integrated transcriptomic and functional analysis.
Khamlaiwong P, Karnmongkol C, Musigapan R et al.
Comp Biochem Physiol C Toxicol Pharmacol·2026·Animal·PubMed →
The potential role of H(2)S in the anti-infective function of antimicrobial peptides.
Wang X, Li S, Shi W et al.
Nat Commun·2026·Animal·Antimicrobial·PubMed →
Immunomodulatory effects of synthetic antimicrobial peptides on LPS-induced inflammatory responses in THP-1 macrophages.
Akbulut I, Zhang Z, Hussell T et al.
Front Immunol·2026·Animal·Antimicrobial, Anti-Inflammatory·PubMed →
Adipocyte-derived CRAMP-neutrophil serine protease interaction axis regulates innate cutaneous defense against Staphylococcus aureus.
Ou M, Wang X, Zhu M et al.
Sci Rep·2026·Animal·Immune Modulation, Wound Healing, Weight Loss·PubMed →
LL-37 IgG levels are associated with clinical characteristics and T follicular cell response in acute coronary syndrome in adults.
Dimayuga PC, Zhou J, Zhao X et al.
Physiol Rep·2026·Animal·PubMed →
Exposure to the antimicrobial peptides LL-37 and ATRA-1 induces a lipidome response in Staphylococcus aureus that alters membrane biophysical properties.
Fuertes-Chaves C, Gonzalez JE, Suesca E et al.
Biochim Biophys Acta Biomembr·2026·Animal·Antimicrobial·PubMed →
Synergistic antibacterial effect of CATH-2 and D-amino acids against mastitis causing gram-positive bacteria.
Veldhuizen EJA, van der Velden ST, Alons D et al.
Front Cell Infect Microbiol·2026·Animal·Antimicrobial·PubMed →
Salivary innate immune peptides are associated with dental caries experience in young adults.
Lozano CP, Echeverría C, García-Manríquez N et al.
Clin Oral Investig·2026·Animal·Immune Modulation, Antimicrobial·PubMed →
Functional characterization of HR-CATH2, a novel cathelicidin from Hoplobatrachus rugulosus with anti-sepsis activity.
Liao H, Lai S, Wang K et al.
Zool Res·2026·Animal·Anti-Inflammatory·PubMed →
Combined nonoxynol-9 and antimicrobial peptide LL-37 for barrier contraception.
Xu M, Chan CPS, Cong L et al.
Reprod Fertil·2026·Animal·Wound Healing·PubMed →
The effect of staphylococcal infection on cathelicidin and β-defensin mRNA levels in epithelial cells lining the mammary gland cistern.
Bagnicka E, Szprynca A, Kościuczuk E et al.
Front Immunol·2026·Animal·PubMed →
Forensic application of CAMP expression for the determination of wound vitality in human compressed neck skin.
Zhang W, Ishida Y, Kuninaka Y et al.
Int J Legal Med·2026·Animal·Wound Healing·PubMed →
Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice.
Brown L, Schlechte J, Rashid M et al.
Science·2026·Animal·PubMed →
Optimized LL-37-Derived Peptides Exhibit Antitubercular Activity, Induce Membrane Disruption, and P-Type ATPase Transcriptional Responses in Mycobacterium tuberculosis.
Santos PA, Maya-Hoyos M, Salazar LM et al.
Biomolecules·2026·Animal·PubMed →
Antimicrobial peptide-derived lipid nanoparticles enable lung-targeted mRNA therapy for multidrug-resistant bacterial pneumonia.
Hou X, Du S, Zhang W et al.
J Control Release·2026·Animal·Antimicrobial·PubMed →
Serine protease HtrA promotes Campylobacter jejuni intestinal colonization through degrading antimicrobial peptide LL-37.
Li X, Zhang M, Xu Z et al.
Sci Adv·2026·Animal·Antimicrobial·PubMed →
Human cathelicidin peptide LL-37 compacts nucleic acids and alters neutrophil extracellular trap structure.
Zielke C, Rad B, Nielsen JE et al.
Sci Rep·2026·Animal·PubMed →
Changes in Antimicrobial Component Concentrations in Goat Milk Following Intramammary Lipopolysaccharide Administration.
Jaisue J, Nishimura M, Suzuki N et al.
Anim Sci J·2026·Animal·Antimicrobial, Anti-Inflammatory·PubMed →
Combined antimicrobial and pro-healing effects of cathelicidins in a polysaccharide-based hydrogel scaffold: treatment of carbapenemase-resistant Pseudomonas aeruginosa wound infections in a porcine model.
Pavelka A, Lipový B, Janda L et al.
Int J Pharm·2026·Animal·Antimicrobial, Wound Healing·PubMed →
Three-dimensional culture enhances the antimicrobial activity of mesenchymal stem cells against Shiga toxin-producing Escherichia coli O157:H7 in vitro.
Bicer M, Öztürk E, Sener F et al.
J Appl Microbiol·2026·Animal·Antimicrobial·PubMed →
How cholesterol modulates LL-37 function: A biophysical study in eukaryotic-like membrane systems.
Giraldo-Lorza JM, Hernández Martínez SA, Sierra-Valdez FJ et al.
Biophys Chem·2026·Animal·PubMed →
Rational engineering of a novel cationic LL-37-temporin SHa hybrid peptide with anti-parasitic activity and effects on mitochondrial membrane potential in protozoan parasites.
Khurshid K, Mughal MAS, Khan JM et al.
Microb Pathog·2026·Animal·PubMed →
SMAP29: an antibacterial peptide that possesses anti-inflammatory and fast bactericidal actions against colistin-resistant gram-negative bacteria.
Zeng Z, Wei M, Zhao D et al.
Microbiol Spectr·2026·Animal·Antimicrobial, Anti-Inflammatory·PubMed →
Vitamin D boosts HIV-1 resistance in female genital epithelial cells by enhancing antiviral cathelicidin expression.
Gonzalez SM, Aguilar-Jimenez W, Rugeles MT et al.
Front Immunol·2026·Animal·PubMed →
Comparative molecular characterisation of myeloid cathelicidins reveals subspecies-level diversification in indigenous livestock.
Roy J, Panicker VP, Madhavan V et al.
Dev Comp Immunol·2026·Animal·Immune Modulation·PubMed →
Role of Bruton's Tyrosine Kinase in mast cell driven urothelial barrier injury in an LL-37 induced model of interstitial cystitis.
Wang G, Li BS, Chu JY et al.
Sci Rep·2026·Animal·PubMed →
LL-37 Inhibits EV71 Infection by Upregulating STAC via the EGFR-ERK Signaling Pathway.
Zhang J, Zhang H, Chen Y et al.
Viruses·2026·Animal·PubMed →
Host antimicrobial peptide LL-37 inhibits CovS kinase activity and antagonizes CovR-Mediated activation in group A Streptococcus.
Wu L, Wang L, Chen S et al.
Biochem Biophys Res Commun·2026·Animal·Antimicrobial·PubMed →
Antimicrobial Peptides and Systemic Inflammation: A Network Analysis.
Pinheiro da Silva F, Soriano FG, Hajjar LA
Immun Inflamm Dis·2026·Animal·Anti-Inflammatory, Immune Modulation, Antimicrobial·PubMed →
Targeting Drug-Resistant Tuberculosis with Antimicrobial Peptides: Opportunities and Challenges.
Ahmad A, Wasim R, Islam A et al.
Curr Protein Pept Sci·2026·Animal·PubMed →
LL-37-ApoB-100 Complex Serves as a Biomarker of Coronary Artery Disease.
Fang Y, Zhang Z, Cao Q et al.
Arterioscler Thromb Vasc Biol·2026·Animal·PubMed →
Skin-Homing Potential of Peripheral Immune Cells From Psoriasis Patients and the Effects of LL-37 on Their Secretion of Chemokines During Psoriasis-Mimicking Stimulation.
Sigurgrímsdóttir H, Eysteinsdóttir JH, Kristjánsson ÁK et al.
Scand J Immunol·2025·Human·Wound Healing·PubMed →
No difference in inflammatory mediator expression between mast cell-rich and mast cell-poor rosacea lesions in Korean patients: a comparative study.
Lee JJ, Kwon BR, Lee MY et al.
Ewha Med J·2025·Human·PubMed →
Assessment of serum cathelicidin in chronic spontaneous urticaria patients.
El Mahdi AR, Melek N, AbdAllah AM et al.
Egypt J Immunol·2025·Human·PubMed →