Research Index
KPV Research Index
PSI surfaces 27 peer-reviewed studies on KPV, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
27 studies
Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Rodrigues JM, Ferreira Leal AP, Buccini DF et al.
Drug Discov Today·2025·Review·GI Protection, Antimicrobial·PubMed →
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.
Gravina AG, Pellegrino R, Durante T et al.
Cells·2023·Review·GI Protection, Anti-Inflammatory·PubMed →
Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.
Sun J, Xue P, Liu J et al.
ACS Biomater Sci Eng·2021·Animal·PubMed →
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes.
Can VC, Locke IC, Kaneva MK et al.
Eur J Pharmacol·2020·Animal·Anti-Inflammatory, Osteoarthritis·PubMed →
Are melanocortin peptides future therapeutics for cutaneous wound healing?
Böhm M, Luger T
Exp Dermatol·2019·Animal·Anti-Inflammatory, Wound Healing·PubMed →
Structural modification of the tripeptide KPV by reductive "glycoalkylation" of the lysine residue.
Songok AC, Panta P, Doerrler WT et al.
PLoS One·2018·Animal·PubMed →
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.
Zeng M, Shao A, Li H et al.
ACS Appl Mater Interfaces·2017·Animal·PubMed →
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.
Xiao B, Xu Z, Viennois E et al.
Mol Ther·2017·Animal·Anti-Inflammatory·PubMed →
Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.
Land SC
Int J Physiol Pathophysiol Pharmacol·2012·Animal·PubMed →
Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone.
Böhm M, Apel M, Sugawara K et al.
J Allergy Clin Immunol·2012·Animal·Anti-Inflammatory·PubMed →
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.
Brzoska T, Böhm M, Lügering A et al.
Adv Exp Med Biol·2010·Review·Anti-Inflammatory·PubMed →
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.
Kannengiesser K, Maaser C, Heidemann J et al.
Inflamm Bowel Dis·2008·Animal·GI Protection·PubMed →
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.
Brzoska T, Luger TA, Maaser C et al.
Endocr Rev·2008·Review·Anti-Inflammatory·PubMed →
alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.
Luger TA, Brzoska T
Ann Rheum Dis·2007·Animal·Anti-Inflammatory·PubMed →
Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide.
Bonfiglio V, Camillieri G, Avitabile T et al.
Exp Eye Res·2006·Animal·Wound Healing·PubMed →
Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions.
Gatti S, Carlin A, Sordi A et al.
J Surg Res·2006·Animal·PubMed →
Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.
Kelly JM, Moir AJ, Carlson K et al.
Peptides·2006·Animal·PubMed →
Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2.
Catania A, Grieco P, Randazzo A et al.
J Pept Res·2005·Animal·PubMed →
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.
Elliott RJ, Szabo M, Wagner MJ et al.
J Invest Dermatol·2004·Animal·PubMed →
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.
Getting SJ, Schiöth HB, Perretti M
J Pharmacol Exp Ther·2003·Animal·Anti-Inflammatory·PubMed →
New insights into the functions of alpha-MSH and related peptides in the immune system.
Luger TA, Scholzen TE, Brzoska T et al.
Ann N Y Acad Sci·2003·Review·Immune Modulation·PubMed →
Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats.
Liu DH, Su YP, Zhang W et al.
Burns·2002·Animal·Wound Healing, Liver Protection·PubMed →
[Changes in aldosterone binding activity of kidney cytosol after stress in rats and the regulation].
Liu DH, Su YP, Zhang W et al.
Sheng Li Xue Bao·2001·Animal·Wound Healing·PubMed →
Alpha-melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes.
Barcellini W, Colombo G, La Maestra L et al.
J Leukoc Biol·2000·Animal·PubMed →
Antimicrobial effects of alpha-MSH peptides.
Cutuli M, Cristiani S, Lipton JM et al.
J Leukoc Biol·2000·Animal·PubMed →
The neuropeptide alpha-MSH in host defense.
Catania A, Cutuli M, Garofalo L et al.
Ann N Y Acad Sci·2000·Review·Immune Modulation·PubMed →
The neuroimmunomodulatory peptide alpha-MSH.
Ichiyama T, Sato S, Okada K et al.
Ann N Y Acad Sci·2000·Review·PubMed →