Research Index
Ipamorelin Research Index
PSI surfaces 50 peer-reviewed studies on Ipamorelin, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
Coutinho LFD, DE Oliveira Neves LF, Camilo RP
J Sports Med Phys Fitness·2026·Animal·PubMed →
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Mavrych V, Shypilova I, Bolgova O
Front Aging·2026·Review·PubMed →
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Mendias CL, Awan TM
Sports Med·2026·Review·PubMed →
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA
J Am Acad Orthop Surg Glob Res Rev·2026·Review·Wound Healing·PubMed →
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.
Mayfield CK, Bolia IK, Feingold CL et al.
Am J Sports Med·2026·Review·PubMed →
The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.
Lu Z, Ngan MP, Liu JYH et al.
Physiol Behav·2024·Animal·Weight Loss·PubMed →
The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus.
Gouda M, Ganesh CB
Anim Reprod Sci·2024·Animal·PubMed →
Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.
N Mohammadi E, Louwies T, Pietra C et al.
J Exp Pharmacol·2020·Animal·PubMed →
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Sinha DK, Balasubramanian A, Tatem AJ et al.
Transl Androl Urol·2020·Review·PubMed →
Glycine-modified growth hormone secretagogues identified in seized doping material.
Gajda PM, Holm NB, Hoej LJ et al.
Drug Test Anal·2019·Animal·GH Activity·PubMed →
Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor.
Fowkes MM, Lalonde T, Yu L et al.
Eur J Med Chem·2018·Animal·GH Activity·PubMed →
A stable meta-carborane enables the generation of boron-rich peptide agonists targeting the ghrelin receptor.
Worm DJ, Els-Heindl S, Kellert M et al.
J Pept Sci·2018·Animal·PubMed →
Analysis of new growth promoting black market products.
Krug O, Thomas A, Malerød-Fjeld H et al.
Growth Horm IGF Res·2018·Animal·GH Activity·PubMed →
Doping control container for urine stabilization: a pilot study.
Tsivou M, Giannadaki E, Hooghe F et al.
Drug Test Anal·2017·Human·PubMed →
Structure-activity relationship for peptídic growth hormone secretagogues.
Ferro P, Krotov G, Zvereva I et al.
Drug Test Anal·2017·Animal·PubMed →
Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.
Thomas A, Görgens C, Guddat S et al.
J Sep Sci·2016·Animal·PubMed →
Solid-phase extraction of small biologically active peptides on cartridges and microelution 96-well plates from human urine.
Semenistaya E, Zvereva I, Krotov G et al.
Drug Test Anal·2016·Animal·PubMed →
Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin.
Semenistaya E, Zvereva I, Thomas A et al.
Drug Test Anal·2015·Animal·PubMed →
Detection of GHRP-2 and GHRP-6 in urine samples from athletes.
Cox HD, Hughes CM, Eichner D
Drug Test Anal·2015·Animal·PubMed →
Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients.
Beck DE, Sweeney WB, McCarter MD et al.
Int J Colorectal Dis·2014·Human·PubMed →
A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography.
Timms M, Hall N, Levina V et al.
Drug Test Anal·2014·Animal·GH Activity·PubMed →
Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry.
Kwok WH, Ho EN, Lau MY et al.
Anal Bioanal Chem·2013·Animal·PubMed →
Metabolism of growth hormone releasing peptides.
Thomas A, Delahaut P, Krug O et al.
Anal Chem·2012·Animal·GH Activity·PubMed →
Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.
Thomas A, Walpurgis K, Krug O et al.
J Chromatogr A·2012·Animal·PubMed →
Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus.
Greenwood-Van Meerveld B, Tyler K, Mohammadi E et al.
J Exp Pharmacol·2012·Animal·PubMed →
Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.
Thomas A, Höppner S, Geyer H et al.
Anal Bioanal Chem·2011·Animal·GH Activity·PubMed →
Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.
Venkova K, Mann W, Nelson R et al.
J Pharmacol Exp Ther·2009·Animal·Weight Loss·PubMed →
Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats.
Aagaard NK, Grøfte T, Greisen J et al.
Growth Horm IGF Res·2009·Animal·GH Activity, Liver Protection·PubMed →
Seabream ghrelin: cDNA cloning, genomic organization and promoter studies.
Yeung CM, Chan CB, Woo NY et al.
J Endocrinol·2006·Animal·GH Activity·PubMed →
Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats.
Adeghate E, Ponery AS
Neuro Endocrinol Lett·2004·Animal·PubMed →
Stimulation of growth hormone secretion from seabream pituitary cells in primary culture by growth hormone secretagogues is independent of growth hormone transcription.
Chan CB, Fung CK, Fung W et al.
Comp Biochem Physiol C Toxicol Pharmacol·2004·Animal·GH Activity·PubMed →
[Ghrelin-related drugs: clinical perspectives].
Shimatsu A
Nihon Rinsho·2004·Review·GH Activity, Sleep·PubMed →
[Structure-activity relationship of ghrelin].
Minamitake Y
Nihon Rinsho·2004·Review·PubMed →
Growth hormone (GH) hypersecretion and GH receptor resistance in streptozotocin diabetic mice in response to a GH secretagogue.
Johansen PB, Segev Y, Landau D et al.
Exp Diabesity Res·2003·Animal·GH Activity, Liver Protection·PubMed →
The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency.
Peschke B, Ankersen M, Bauer M et al.
Eur J Med Chem·2002·Animal·GH Activity·PubMed →
Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro.
Jiménez-Reina L, Cañete R, de la Torre MJ et al.
Histol Histopathol·2002·Animal·Weight Loss, GH Activity·PubMed →
The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats.
Andersen NB, Malmlöf K, Johansen PB et al.
Growth Horm IGF Res·2001·Animal·Muscle Recovery·PubMed →
Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin.
Hansen TK, Ankersen M, Raun K et al.
Bioorg Med Chem Lett·2001·Animal·GH Activity·PubMed →
Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues.
Matsumoto M, Kitajima Y, Iwanami T et al.
Biochem Biophys Res Commun·2001·Animal·PubMed →
Do growth hormone-releasing peptides act as ghrelin secretagogues?
Ahnfelt-Rønne I, Nowak J, Olsen UB
Endocrine·2001·Animal·GI Protection, GH Activity·PubMed →
Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.
Lall S, Tung LY, Ohlsson C et al.
Biochem Biophys Res Commun·2001·Animal·Weight Loss, GH Activity·PubMed →
The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats.
Svensson J, Lall S, Dickson SL et al.
J Endocrinol·2000·Animal·Weight Loss·PubMed →
Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.
Gobburu JV, Agersø H, Jusko WJ et al.
Pharm Res·1999·Human·GH Activity·PubMed →
Methylprednisolone does not inhibit the release of growth hormone after intravenous injection of a novel growth hormone secretagogue in rats.
Malmlöf K, Johansen PB, Haahr PM et al.
Growth Horm IGF Res·1999·Animal·Weight Loss, GH Activity·PubMed →
Pharmacological characterisation of a new oral GH secretagogue, NN703.
Hansen BS, Raun K, Nielsen KK et al.
Eur J Endocrinol·1999·Animal·GH Activity·PubMed →
Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats.
Johansen PB, Nowak J, Skjaerbaek C et al.
Growth Horm IGF Res·1999·Animal·Weight Loss, Bone Healing·PubMed →
Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption.
Johansen PB, Hansen KT, Andersen JV et al.
Xenobiotica·1998·Animal·GH Activity·PubMed →
Ipamorelin, the first selective growth hormone secretagogue.
Raun K, Hansen BS, Johansen NL et al.
Eur J Endocrinol·1998·Animal·GH Activity·PubMed →
Novel orally active growth hormone secretagogues.
Hansen TK, Ankersen M, Hansen BS et al.
J Med Chem·1998·Animal·GH Activity·PubMed →
A new series of highly potent growth hormone-releasing peptides derived from ipamorelin.
Ankersen M, Johansen NL, Madsen K et al.
J Med Chem·1998·Animal·GH Activity·PubMed →