Research Index
Humanin Research Index
PSI surfaces 50 peer-reviewed studies on Humanin, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].
Li CY, Zhang NN, Yang YL et al.
Zhonghua Xin Xue Guan Bing Za Zhi·2026·Human·PubMed →
Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.
Bolignano D, Greco M, Pugliese S et al.
Cardiorenal Med·2026·Human·Cardiovascular Risk·PubMed →
Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients.
Demirkiran C, Mete A, Demiryürek AT et al.
Curr Eye Res·2026·Human·PubMed →
Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection.
Zhong Y, Haishaer D, Cai W et al.
Pathogens·2026·Animal·Liver Protection, Anti-Inflammatory·PubMed →
Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses.
Ramazan SB, Turan B, Turkkol A et al.
Cytotechnology·2026·Animal·PubMed →
S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.
Abueid L, Torun AF, Golal E et al.
Exp Physiol·2026·Animal·PubMed →
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Suliman ME, Rahman A, Qureshi AR et al.
Antioxidants (Basel)·2026·Animal·PubMed →
Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).
Shahzaib M, Aprile D, Laporta G et al.
Biomolecules·2026·Animal·PubMed →
S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.
Liu Y, Hu C, Luo S et al.
Eur J Pharmacol·2026·Animal·PubMed →
Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
Köm Akipek RE, Çoban Ercan E, Akipek ME et al.
Reprod Biol·2026·Animal·PubMed →
Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.
Lin B, Schneider K, Ozgul M et al.
Sci Rep·2026·Animal·PubMed →
Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.
Dagli S, Oyur ME, Turan B et al.
Ups J Med Sci·2026·Animal·Glycemic Control·PubMed →
Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.
Bulut F, Adam M, Hekim MG et al.
Biology (Basel)·2026·Animal·PubMed →
Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.
Hekim MG, Kaya Tektemur N, Ozcan M
Exp Physiol·2026·Animal·PubMed →
Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.
Conte JG, Reynoso S, Gosso MS et al.
Reproduction·2026·Animal·PubMed →
Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.
Bulut F, Adam M, Ozgen A et al.
Metabolites·2026·Animal·PubMed →
Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
Jang HY, Choi S, Kim SJ et al.
Aging Cell·2026·Animal·PubMed →
Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.
Zingarelli B
Am J Respir Cell Mol Biol·2026·Animal·PubMed →
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.
Lin B, Schneider K, Ozgul M et al.
Res Sq·2026·Animal·PubMed →
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Liao Y, Xu J, Jiao Y et al.
Biomedicines·2026·Animal·PubMed →
Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
Wu X, Li Y, Lin X et al.
Am J Respir Cell Mol Biol·2026·Animal·PubMed →
Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
Shan Y, Liu X, Ge W et al.
Toxicol Ind Health·2026·Animal·PubMed →
[Humanin: a mitochondria-hidden peptide serving inflammation resolution].
Maraux M, Saas P, Cherrier T
Med Sci (Paris)·2026·Animal·PubMed →
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.
Lin B, Schneider K, Ozgul M et al.
bioRxiv·2026·Animal·PubMed →
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
Shahzaib M, Aprile D, Alessio N et al.
Free Radic Biol Med·2026·Animal·PubMed →
Characterization of the Effects of a Humanin Fragment Peptide (HNF(14)) in Age-Related Macular Degeneration.
Nashine S, Kenney MC
J Clin Med·2026·Animal·PubMed →
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Elhusseiny R, Ihsan M, Bellefroid T et al.
Physiol Rep·2026·Animal·PubMed →
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
Gemeda AE, Singh M, Katiyar R et al.
Sci Rep·2026·Animal·PubMed →
Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
Cedervall T, Jude B, von Walden F et al.
Biochem Biophys Rep·2026·Animal·PubMed →
Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
Mohamed MH, Kamel WT, Ibrahim EH et al.
Discov Oncol·2026·Animal·PubMed →
Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.
Kutuk IS, Akin S, Demirel H et al.
J Endocrinol Invest·2026·Animal·Muscle Recovery, Glycemic Control·PubMed →
Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids.
Mohtashami Z, Schneider K, Azimi R et al.
Hum Cell·2025·Human·PubMed →
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.
Coradduzza D, Cruciani S, Di Lorenzo B et al.
Noncoding RNA·2025·Human·PubMed →
Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
Vicinanza R, Cammisotto V, Wan J et al.
Front Nutr·2025·Animal·PubMed →
SHLP2 restores pre-osteoblastic cells against oxidative stress-induced inflammaging.
Ryu JH, Mangal U, Kim JH et al.
Sci Rep·2025·Animal·Anti-Inflammatory·PubMed →
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
Rodríguez-Esparragón F, Cazorla-Rivero SE, Torrealba E et al.
Int J Mol Sci·2025·Animal·Longevity·PubMed →
Herkinorin Promotes μ-Opioid Receptor Internalization and Protects iPSC-Derived Neurons from Hypoxic/Ischemic Injury.
Ju Z, Wang G, Yan Y et al.
J Integr Neurosci·2025·Animal·Neuroprotection·PubMed →
Hierarchical random forest model, inflammation and oxidative stress as predictors of the atherogenic index of plasma and diabetes progression.
Jelinek HF, Muteir I, Al-Aubaidy H
Sci Rep·2025·Animal·Glycemic Control, Anti-Inflammatory, Cardiovascular Risk·PubMed →
Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure.
Asil H, Demiryürek AT, Düzen IV et al.
Eur J Pharmacol·2024·Human·Glycemic Control·PubMed →
Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.
Bolignano D, Greco M, Presta P et al.
J Nephrol·2024·Human·Cardiovascular Risk·PubMed →
Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease.
Savvopoulos S, Hatzikirou H, Jelinek HF
Biomark Insights·2024·Human·PubMed →
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy.
Huth A, Ayoub I, Barateau L et al.
J Autoimmun·2024·Human·PubMed →
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
Kavak AG, Karslioglu I, Saracaloglu A et al.
Curr Radiopharm·2024·Human·PubMed →
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
Saracaloglu A, Mete AÖ, Ucar DF et al.
Curr Protein Pept Sci·2023·Human·PubMed →
Humanin gene expression in subjects with Parkinson's disease.
Salemi M, Ridolfo F, Salluzzo MG et al.
Mol Biol Rep·2023·Human·PubMed →
Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.
Cai H, Cao P, Sun W et al.
Biochim Biophys Acta Gen Subj·2022·Human·Anti-Inflammatory·PubMed →
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
von Walden F, Fernandez-Gonzalo R, Norrbom J et al.
J Appl Physiol (1985)·2021·Human·Muscle Recovery·PubMed →
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
Wang Y, Li N, Zeng Z et al.
Mol Hum Reprod·2021·Human·PubMed →
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
Raijmakers RPH, Jansen AFM, Keijmel SP et al.
J Transl Med·2019·Human·PubMed →
[The level of circulating humanin in patients with ischemic heart disease.].
Zhloba AA, Subbotina TF, Molchan NS et al.
Klin Lab Diagn·2018·Human·PubMed →