Research Index
Humanin Research Index
PSI surfaces 50 peer-reviewed studies on Humanin, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients.
Demirkiran C, Mete A, Demiryürek AT et al.
Curr Eye Res·2026 ·Human·PubMed →
Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
Shan Y, Liu X, Ge W et al.
Toxicol Ind Health·2026·Animal·PubMed →
[Humanin: a mitochondria-hidden peptide serving inflammation resolution].
Maraux M, Saas P, Cherrier T
Med Sci (Paris)·2026·Animal·PubMed →
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.
Lin B, Schneider K, Ozgul M et al.
bioRxiv·2026·Animal·PubMed →
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
Shahzaib M, Aprile D, Alessio N et al.
Free Radic Biol Med·2026·Animal·PubMed →
Characterization of the Effects of a Humanin Fragment Peptide (HNF(14)) in Age-Related Macular Degeneration.
Nashine S, Kenney MC
J Clin Med·2026·Animal·PubMed →
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Elhusseiny R, Ihsan M, Bellefroid T et al.
Physiol Rep·2026·Animal·Muscle Recovery·PubMed →
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
Gemeda AE, Singh M, Katiyar R et al.
Sci Rep·2026·Animal·PubMed →
Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
Cedervall T, Jude B, von Walden F et al.
Biochem Biophys Rep·2026·Animal·PubMed →
Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
Mohamed MH, Kamel WT, Ibrahim EH et al.
Discov Oncol·2026·Animal·PubMed →
Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.
Kutuk IS, Akin S, Demirel H et al.
J Endocrinol Invest·2026·Animal·PubMed →
Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids.
Mohtashami Z, Schneider K, Azimi R et al.
Hum Cell·2025·Human·PubMed →
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.
Coradduzza D, Cruciani S, Di Lorenzo B et al.
Noncoding RNA·2025·Human·PubMed →
Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
Vicinanza R, Cammisotto V, Wan J et al.
Front Nutr·2025·Animal·PubMed →
SHLP2 restores pre-osteoblastic cells against oxidative stress-induced inflammaging.
Ryu JH, Mangal U, Kim JH et al.
Sci Rep·2025·Animal·PubMed →
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
Rodríguez-Esparragón F, Cazorla-Rivero SE, Torrealba E et al.
Int J Mol Sci·2025·Animal·Longevity·PubMed →
Herkinorin Promotes μ-Opioid Receptor Internalization and Protects iPSC-Derived Neurons from Hypoxic/Ischemic Injury.
Ju Z, Wang G, Yan Y et al.
J Integr Neurosci·2025·Animal·Neuroprotection·PubMed →
Hierarchical random forest model, inflammation and oxidative stress as predictors of the atherogenic index of plasma and diabetes progression.
Jelinek HF, Muteir I, Al-Aubaidy H
Sci Rep·2025·Animal·Glycemic Control, Anti-Inflammatory, Cardiovascular Risk·PubMed →
Exercise Improves Cardiac Dysfunction in D-Galactose-Treated Rats by Regulation of IGF-1-Humanin Pathway.
Askarimoghadam H, Rostamzadeh F, Mirtajaddini Goki M et al.
J Aging Res·2025·Animal·PubMed →
In-silico modeling of SHLP6: A novel mitochondrial peptide controlling neurodegeneration and cellular aging.
Kannan HT, Umapathy S, Pan I
Comput Biol Med·2025·Animal·PubMed →
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
Maraux M, Vetter M, Zuffo LD et al.
Cell Death Dis·2025·Animal·Anti-Inflammatory·PubMed →
Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.
Chouksey S, Shukla SN, Dubey A et al.
Reprod Domest Anim·2025·Animal·PubMed →
S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.
Huang J, Zhang D, Zou L et al.
Mol Hum Reprod·2025·Animal·PubMed →
Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.
Coradduzza D, Cruciani S, Sibono L et al.
Clin Exp Med·2025·Animal·PubMed →
Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.
Huang J, Liu Y, Zou L et al.
Reprod Biomed Online·2025·Animal·PubMed →
SHLP6: a novel NLRP3 and Cav1 modulating agent in Cu-induced oxidative stress and neurodegeneration.
Thamarai Kannan H, Umapathy S, Pan I
Front Mol Neurosci·2025·Animal·PubMed →
Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study.
Zhu D, Wang Z, Li Y et al.
J Orthop Translat·2025·Animal·PubMed →
Humanin alone and in combination with GnRHa therapy attenuates ovarian dysfunction induced by prepubertal cyclophosphamide chemotherapy in female mice.
Liu L, Wang H, Wen W et al.
Reprod Toxicol·2025·Animal·PubMed →
Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.
Bilgin B, Hekim MG, Bulut F et al.
Neuropharmacology·2025·Animal·Anti-Inflammatory·PubMed →
Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure.
Asil H, Demiryürek AT, Düzen IV et al.
Eur J Pharmacol·2024·Human·Glycemic Control·PubMed →
Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.
Bolignano D, Greco M, Presta P et al.
J Nephrol·2024·Human·Cardiovascular Risk·PubMed →
Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease.
Savvopoulos S, Hatzikirou H, Jelinek HF
Biomark Insights·2024·Human·PubMed →
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy.
Huth A, Ayoub I, Barateau L et al.
J Autoimmun·2024·Human·PubMed →
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
Kavak AG, Karslioglu I, Saracaloglu A et al.
Curr Radiopharm·2024·Human·PubMed →
[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.
Li M, Liu Z, Cao X et al.
Sci Rep·2024·Animal·Longevity·PubMed →
Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.
Amman AM, Wolfe V, Piraino G et al.
Biomedicines·2024·Animal·PubMed →
Mitochondrial-derived peptides, HNG and SHLP3, protect cochlear hair cells against gentamicin.
Lu Y, Bartoszek EM, Cortada M et al.
Cell Death Discov·2024·Animal·PubMed →
Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.
Shi Q, Xiao Z, Cai W et al.
Biochem Biophys Res Commun·2024·Animal·PubMed →
Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles.
Hyatt JK, Lu EJ, McCall GE
Front Physiol·2024·Animal·PubMed →
Rational fusion design inspired by cell-penetrating peptide: SS31/S-14 G Humanin hybrid peptide with amplified multimodal efficacy and bio-permeability for the treatment of Alzheimer's disease.
Qian K, Yang P, Li Y et al.
Asian J Pharm Sci·2024·Animal·PubMed →
Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.
Wang J, Wen W, Liu L et al.
Reprod Toxicol·2024·Animal·PubMed →
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
Saracaloglu A, Mete AÖ, Ucar DF et al.
Curr Protein Pept Sci·2023·Human·PubMed →
Humanin gene expression in subjects with Parkinson's disease.
Salemi M, Ridolfo F, Salluzzo MG et al.
Mol Biol Rep·2023·Human·PubMed →
Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.
Cai H, Cao P, Sun W et al.
Biochim Biophys Acta Gen Subj·2022·Human·Anti-Inflammatory·PubMed →
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
von Walden F, Fernandez-Gonzalo R, Norrbom J et al.
J Appl Physiol (1985)·2021·Human·Muscle Recovery·PubMed →
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
Wang Y, Li N, Zeng Z et al.
Mol Hum Reprod·2021·Human·PubMed →
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
Raijmakers RPH, Jansen AFM, Keijmel SP et al.
J Transl Med·2019·Human·PubMed →
[The level of circulating humanin in patients with ischemic heart disease.].
Zhloba AA, Subbotina TF, Molchan NS et al.
Klin Lab Diagn·2018·Human·PubMed →
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.
Yen K, Wan J, Mehta HH et al.
Sci Rep·2018·Human·Cognitive Enhancement, Neuroprotection·PubMed →
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
Nashine S, Cohen P, Chwa M et al.
Cell Death Dis·2017·Human·PubMed →