Research Index

Glycine-Proline-Glutamate (GPE) Research Index

PSI surfaces 50 peer-reviewed studies on Glycine-Proline-Glutamate (GPE), prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.

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50 studies

Patients' Lived Experiences of Spasticity.

Bhimani R, Xiong JB, Anderson L

Phys Med Rehabil Clin N Am·2026·Human·PubMed →

Patient Perceptions of a Preventive Effect of Long-Term Botulinum Neurotoxin Therapy in Cervical Dystonia.

Hefter H, Samadzadeh S

Toxins (Basel)·2026·Human·PubMed →

LetibotulinumtoxinA for Rosacea: A Pilot Study.

Bańka-Wrona A, Wrona W, Barańska-Rybak W

Toxins (Basel)·2026·Human·Wound Healing·PubMed →

Longitudinal Computed Tomographic Evaluation of Mandibular Bone Morphology Following OnabotulinumtoxinA Treatment of Masseter Muscle Prominence: Results of a 12-Month, Repeat-Treatment, Placebo-Controlled Study in Healthy Adults.

Mallya SM, Kostenuik P, Hopfinger R et al.

Aesthet Surg J·2026·Human·PubMed →

Adverse neurological events following botulinum toxin type A: A case series of post-injection seizures and paralysis.

Li Q, Dai C, Wang H et al.

Toxicon X·2026·Human·PubMed →

Influence of Preoperative Cognitive Function, Self-Efficacy, and Postoperative Psychological Counselling on Anxiety and Depression Levels in Patients Undergoing Botulinum Toxin Injections.

Yu X, Zhang Y, Zhang L et al.

Actas Esp Psiquiatr·2026·Human·Cognitive Enhancement, Anxiety & Mood·PubMed →

Morphea En Coup De Sabre Treated With Combination Hyaluronic Acid Filler and Neuromodulator: A Case Report.

Jensen C, Remington BK

Cureus·2026·Human·PubMed →

Comparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting.

Singh B, Singla M, Kaushal H et al.

Cureus·2026·Human·PubMed →

Long-Term Outcomes of Preoperative Botulinum Toxin Use in Abdominal Wall Reconstruction: A Propensity-Matched Analysis of More Than 5000 Patients Over 5 Years.

Tanas Y, Chen S, Nguyen P et al.

Aesthet Surg J Open Forum·2026·Human·PubMed →

Atypical Respiratory Presentation of Pediatric Achalasia: A Case Report.

Munoz J, McClain A, Larson J et al.

Cureus·2026·Human·PubMed →

Botulinum Toxin Type A as an Early Intervention for Traumatic Oculomotor Nerve Palsy: A Pediatric Case Report.

Koiwa C, Negishi T, Ito M et al.

Cureus·2026·Human·PubMed →

Minimally Invasive Aesthetic Treatments for the Corrective Patient Archetype: Transforming Lives.

Shturman I, Garzón H, Coimbra D et al.

Aesthetic Plast Surg·2026·Human·PubMed →

[Experience of using Relatox in the complex rehabilitation of patients with lower limb spasticity after focal brain damage of various etiologies].

Khatkova SE, Krainova JS

Zh Nevrol Psikhiatr Im S S Korsakova·2026·Human·Neuroprotection·PubMed →

Unusual reflex tearing during micturition and defecation: a case report.

Alabdullah ZA, Alsubhi SS, Albadri KS

Orbit·2026·Human·PubMed →

Correction of Iatrogenic Facial Asymmetry Caused by Botulinum Toxin Using Contralateral Injection: A Case Report.

Bilal MR, Javaid RH, Bilal A

Aesthet Surg J Open Forum·2026·Human·PubMed →

How Would You Manage This Patient With Frequent Migraine Headaches? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Libman H, Smetana GW, Hovaguimian AE et al.

Ann Intern Med·2026·Human·PubMed →

Dubious benefit of three injections of botulinum toxin in refractory chronic neck pain: retrospective data on 22 patients with a 9-month follow-up.

Fakih O, Chouk M, Verhoeven F et al.

Joint Bone Spine·2026·Human·PubMed →

Botulinum toxin type A for Lyell's syndrome-associated dyspareunia: A case report.

Costa FM, Alves M, Carvalho M et al.

Eur J Obstet Gynecol Reprod Biol·2026·Human·PubMed →

Orofacial Drinking Tremor: A Case Series and Literature Review.

Birreci D, Angelini L, Aloisio S et al.

Mov Disord Clin Pract·2026·Human·PubMed →

How Can We Personalize the Delivery of Onabotulinumtoxin-A for Patients With Neurogenic Lower Urinary Tract Dysfunction?

Wang SL, Jaffe WI, Smith AL

Neurourol Urodyn·2026·Human·PubMed →

Safety, tolerability, and efficacy of atogepant added to onabotulinumtoxinA for the preventive treatment of chronic migraine: A phase 3, multicenter, 24-week, open-label study.

Rothrock J, Najib U, Ailani J et al.

Cephalalgia·2026·Human·PubMed →

Nurse-led management of sialorrhea in Parkinson's disease: a pilot randomized controlled trial.

Guan H, Ma X, Jiang C et al.

Front Med (Lausanne)·2026·Human·PubMed →

A plastic surgery approach to Meige syndrome: Botulinum toxin for rebalancing facial dystonia and aesthetics - A case report.

Long X

JPRAS Open·2026·Human·PubMed →

Patient-Reported Outcomes After Treatment With OnabotulinumtoxinA for Platysma Prominence: Results From a Phase 2 Dose-Ranging Study.

Humphrey S, Shimoga S, Kaufman J et al.

J Cosmet Dermatol·2026·Human·Skin & Cosmetic·PubMed →

Comparing patient satisfaction and pain control between vibration and topical anesthesia during botulinum toxin A injections: a randomized, double-blind, split-face clinical trial.

de Carvalho DC, Rodrigues V, da Fonseca Josino FB et al.

J Cosmet Laser Ther·2026·Human·PubMed →

Botulinum toxin injection induced autoimmune thyroiditis and myxedema coma: A case report.

Gazwi K, Zaza T, Mitwally H et al.

SAGE Open Med Case Rep·2026·Human·PubMed →

Efficacy and Safety of LetibotulinumtoxinA Injection for Trapezius Hypertrophy: A Prospective, Randomized, Double-Blind Trial.

Kim TH, Kang HI, Lee SJ et al.

Aesthetic Plast Surg·2026·Human·PubMed →

Dexamethasone Admixture for Hypersensitivity Prevention in Botulinum Toxin Type A Treatment: A Case Report.

Jia X, Liang Y, Chen Q et al.

J Cosmet Dermatol·2026·Human·PubMed →

Pyloric Metrics and Distensibility Plateau by Functional Luminal Imaging Probe in Pediatric Patients: A Pilot Study.

Osgood PT, Hoffmann NV, Wechsler JB et al.

Neurogastroenterol Motil·2026·Human·PubMed →

Neurophysiological assessment of F-, M-waves and cutaneous silent period in patients with caput patterns of cervical dystonia in the waning phase of botulinum toxin therapy.

Drużdż A, Dudzic M, Sowińska A et al.

Neurol Neurochir Pol·2026·Human·PubMed →

Evaluation of transnasal videoendoscopic-guided botulinum toxin injection in patients with adductor spasmodic dysphonia.

Ricard O, Lagrange E, Fraix V et al.

Otolaryngol Pol·2026·Human·PubMed →

Real-World Switch Rates, Treatment Patterns, and Healthcare Costs Among Patients With Spasticity Treated With Botulinum Toxins.

Dominguez A, Shah D, Cheng N et al.

Adv Ther·2026·Human·PubMed →

Iodine-starch test validity in amputee patients with hyperhidrosis.

Hansen C, Godfrey B, Balch A

Disabil Rehabil·2026·Human·PubMed →

Communication Experiences of Neurological Voice Disorder Patients With Automatic Voice Assistants and Human Listeners.

Ishikawa K, Renkert E, Baratz H et al.

J Voice·2026·Human·PubMed →

Early Use of Botulinum Toxin in Post-Stroke Spasticity Has the Potential to Prevent Post-Stroke Upper Limb Pain-A Secondary Analysis of the EUBoSS Randomised Controlled Trial.

Lindsay C, Philp F, Pandyan AD

Toxins (Basel)·2026·Human·PubMed →

Marginal Orbicularis Oris Hyperactivity (MOOH): An Exploratory Case Series of Inversion-Dominant Upper Lip Dynamics Following Intraoral Botulinum Toxin Type A.

Armenti AF

Toxins (Basel)·2026·Human·PubMed →

Botulinum Toxin Treatment Can Enlarge Eye Appearance in Asian Patients and Improves Social and Emotional Attributes.

de Maio M, Kato K, Sato M et al.

Toxins (Basel)·2026·Human·PubMed →

OnabotulinumToxinA Reduces Pharmacological Burden in Chronic Migraine Patients: A Two-Center Prospective Cohort Study.

Montisano DA, Parisi A, Raggi A et al.

Toxins (Basel)·2026·Human·PubMed →

Is Ready-To-Use AbobotulinumtoxinA More Effective Than OnabotulinumtoxinA for Glabellar Lines? A Randomized, Controlled, Triple-Blinded Clinical Trial.

Gonçalves JR, Valesan LF, Shishido ACLN et al.

J Cosmet Dermatol·2026·Human·Skin & Cosmetic·PubMed →

Predictors of response to botulinum toxin treatment in patients with primary hemifacial spasm: A prospective cohort study.

Jain S, Pandey S, Garg RK et al.

Parkinsonism Relat Disord·2026·Human·PubMed →

Evaluating the efficacy of botulinum toxin type a in alleviating neuropsychological symptoms in hemifacial spasm patients.

Ni X, Yang X, Wang L et al.

Neurol Res·2026·Human·PubMed →

Effects of apomorphine, spinal rTMS, and BoNT on camptocormia: an exploratory wearable sensor-based analysis in a patient with MSA.

De Monte D, Squintani GM, Ermanis G et al.

Toxicon·2026·Human·PubMed →

Topical imiquimod in the management of botulinum toxin-induced upper eyelid ptosis: A case series.

Abou Tayeh S, Merhi R, Khachan MJ et al.

JAAD Case Rep·2026·Human·PubMed →

The Underestimated Burden of Urgency Urinary Incontinence Borne by Older Women.

Cichowski S, Halder GE, Bradley M et al.

Urogynecology (Phila)·2026·Human·PubMed →

Relaxing Environment Lowers Anxiety During Chemodenervation: a Randomized Trial.

Franks E, Rigdon J, Kennelly M et al.

Urogynecology (Phila)·2026·Human·Anxiety & Mood·PubMed →

Enhanced Effectiveness of Onabotulinum Toxin A in Combination With Definisse KP1 Eye Contour Cream for Upper Face Rejuvenation: A Case Series.

Proietti I, Manni M

J Cosmet Dermatol·2026·Human·Skin & Cosmetic·PubMed →

Aesthetic interventions in patients with allergic skin diseases: Risk assessment and evidence-based preventive risk management.

Yiğit İK, Türsen Ü, Türsen B et al.

Clin Dermatol·2026·Human·PubMed →

Sialocele following excision of delayed-onset inflamed facial fat graft: A case report.

Ma IZ, Yoon S, Park JW et al.

Medicine (Baltimore)·2026·Human·PubMed →

Assessment of Quality of Life of Patients with Chronic Migraine on OnabotulinumtoxinA Therapy-A Study Performed at a Super Specialty Tertiary Hospital in Northeast India.

Barkataky N, Ali A, Lihite RJ et al.

Neurol India·2026·Human·PubMed →

Botulinum toxin use in patients with neurological disorders: A U.S.-based claims database analysis.

Simpson DM, Bouchard J, Page S et al.

PM R·2026·Human·PubMed →