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INDEXED STUDIES

GHRP-6 — Indexed Studies

50 most recent studies indexed by PSI from PubMed and clinical databases

Showing 50 of 50 studies

Ghrelin up-regulates cartilage-specific genes via the ERK/STAT3 pathway in chondrocytes of patients with adolescent idiopathic scoliosis.

Liang ZT, Li J, Rong R et al.

Biochem Biophys Res Commun(2019)
Human
PubMed

Insulinotropic action of bombesin-like peptides mediated by gastrin-releasing peptide receptors in steers.

Zhao HQ, Yao G, Yannaing S et al.

J Anim Sci(2016)
Human
Glycemic Control
PubMed

Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.

Wang L, Rodriguez-Ulloa A, Berlanga-Acosta J et al.

Pharmaceuticals (Basel)(2026)
Animal
PubMed

Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis.

Wang L, Berlanga-Acosta J, Yu H et al.

Int Immunopharmacol(2026)
Animal
PubMed

Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption.

Kihara M, Yamagiwa T, Katayama H et al.

Peptides(2026)
Animal
PubMed

Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.

Rahmania A, Zendehdel M, Hassanpour S

Poult Sci(2026)
Animal
Antimicrobial
PubMed

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.

Zhao X, Pan K, Li R et al.

J Nanobiotechnology(2025)
Animal
PubMed

Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.

Wei X, Mulumba M, Chemtob S et al.

J Med Chem(2025)
Animal
PubMed

Assessing The Effectiveness of Growth Hormone Releasing Protein-6 in Improving Human Oocyte Maturation and Meiotic Progression in In Vitro Maturation Culture Media.

Ostadian C, Hayati N, Zahiri Sorouri Z et al.

Int J Fertil Steril(2025)
Animal
PubMed

The Ghrelin Analog GHRP-6, Delivered Through Aquafeeds, Modulates the Endocrine and Immune Responses of Sparus aurata Following IFA Treatment.

Rodríguez-Viera L, Caderno A, Martinez R et al.

Biology (Basel)(2025)
Animal
PubMed

A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade.

Olivier N, Harvey BH, Gobec S et al.

Biomed Pharmacother(2025)
Animal
NeuroprotectionCognitive Enhancement
PubMed

Danshen-Chuanxiong-Honghua ameliorates neurological function and inflammation in traumatic brain injury in rats via modulating Ghrelin/GHSR.

Zhang X, Cai Y, Chen M et al.

J Ethnopharmacol(2025)
Animal
Neuroprotection
PubMed

GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.

Zhu J, Zhou T, Chen G et al.

Vet Res(2025)
Animal
Liver Protection
PubMed

Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke.

Beuker C, Schreiner U, Strecker JK et al.

Neurol Res Pract(2025)
Animal
PubMed

Subchronic safety assessment of CIGB-500 in beagle dog after repeated daily dose administration over 28 days.

Castro J, Shaikh I, Silo S et al.

Regul Toxicol Pharmacol(2025)
Animal
PubMed

Ghrelin suppresses water intake with a different physiological significance from atrial natriuretic peptide in conscious seawater-acclimated eels.

Kaiya H, Nobata S, Takei Y

J Exp Biol(2025)
Animal
PubMed

Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats.

Ayman J, Buzás A, Dochnal R et al.

Biomedicines(2025)
Animal
PubMed

Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.

Poelman R, Le May MV, Schéle E et al.

Endocrinology(2025)
Animal
Neuroprotection
PubMed

Ghrelin is essential for lowering blood pressure during torpor.

Matsui K, Ida T, Oishi K et al.

Front Endocrinol (Lausanne)(2024)
Animal
PubMed

Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.

Zhu J, Zhao H, Aierken A et al.

PLoS Negl Trop Dis(2024)
Animal
Anti-InflammatoryLiver Protection
PubMed

Ghrelin Modulates Voltage-Gated Ca(2+) Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons.

Goudsward HJ, Ruiz-Velasco V, Stella SL et al.

Mol Pharmacol(2024)
Animal
PubMed

Rikkunshito improves anorexia through ghrelin- and orexin-dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats.

Yakabi K, Yamaguchi N, Takayama K et al.

Neurogastroenterol Motil(2024)
Animal
Neuroprotection
PubMed

Novel chimeric peptides based on endomorphins and ghrelin receptor antagonist produced supraspinal antinociceptive effects with reduced acute tolerance in mice.

Wu B, Cheng S, Liu F et al.

Biochimie(2025)
Animal
PubMed

Ghrelin Improves Glucolipotoxicity-Induced Pancreatic β-Cellular Dysfunction and Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Induced IRE1/JNK Pathway.

Li XY, Zhong CR, Wu JC et al.

Discov Med(2024)
Animal
PubMed

Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells.

McKimpson WM, Spiegel S, Mukhanova M et al.

J Cell Biol(2024)
Animal
PubMed

Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms.

Berlanga-Acosta J, Cibrian D, Valiente-Mustelier J et al.

Front Pharmacol(2024)
Animal
PubMed

Ghrelin alleviates intestinal ischemia-reperfusion injury by activating the GHSR-1α/Sirt1/FOXO1 pathway.

Liao SS, Zhang LL, Zhang YG et al.

FASEB J(2024)
Animal
PubMed

Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial.

Hernández-Bernal F, Estenoz-García D, Gutiérrez-Ronquillo JH et al.

Front Neurol(2024)
Animal
PubMed

Ghrelin regulates the endoplasmic reticulum stress signalling pathway in gestational diabetes mellitus.

Li X, Ji Q, Zhong C et al.

Biochem Biophys Res Commun(2024)
Animal
PubMed

Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress.

Luque EM, Díaz-Luján CM, Paira DA et al.

Front Endocrinol (Lausanne)(2023)
Animal
PubMed

Differential impact of a ghrelin receptor antagonist or inverse agonist in the electrical kindling model of epilepsy.

Beheshti S, Ershadi S, Zamani F et al.

Epilepsy Res(2023)
Animal
PubMed

Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST).

Ayman J, Palotai M, Dochnal R et al.

Biomedicines(2023)
Animal
PubMed

In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.

González-López NM, Guerra-Acero-Turizo LM, Blanco-Medina I et al.

Biomed Chromatogr(2023)
Animal
GH Activity
PubMed

Desacylghrelin modulates GHS-R1 receptor expression and cell differentiation in placental BeWo cells.

Coria-Caballero V, Jaramillo-Narvaez MD, Leon-Verdin MG et al.

Mol Cell Endocrinol(2023)
Animal
PubMed

Inhibition of ghrelin activity by the receptor antagonist [D-Lys3]-GHRP-6 enhances hepatic fatty acid oxidation and gluconeogenesis in a growing pig model.

Zhang H, Yan X, Lin A et al.

Peptides(2023)
Animal
Liver ProtectionWeight Loss
PubMed

The effects and mechanisms of ghrelin upon angiogenesis in human coronary artery endothelial cells under hypoxia.

Wang L, Chen Q, Pang J

Peptides(2023)
Animal
PubMed

Intracerebroventricular injection of ghrelin receptor antagonist alleviated NAFLD via improving hypothalamic insulin resistance.

Gong Y, Guo Y, Jiang Y et al.

Iran J Basic Med Sci(2022)
Animal
PubMed

Ghrelin Downregulates Lipopolysaccharide/ Leptin-Induced MUC5AC Expression in Human Nasal Epithelial Cells.

Choi YS, Na HG, Bae CH et al.

Clin Exp Otorhinolaryngol(2023)
Animal
PubMed

Temporal patterns of increased growth hormone secretion in mice after oral administration of L-ornithine: possible involvement of ghrelin receptors.

Taniguchi E, Hattori A, Kurogi K et al.

J Vet Med Sci(2022)
Animal
GH Activity
PubMed

Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry.

Liu YL, Xu JJ, Han LR et al.

Chin J Integr Med(2023)
Animal
Anxiety & Mood
PubMed

Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD 1067.

Shin HJ, Bak SU, La HN et al.

Sci Rep(2022)
Animal
GH Activity
PubMed

Antagonization of Ghrelin Suppresses Muscle Protein Deposition by Altering Gut Microbiota and Serum Amino Acid Composition in a Pig Model.

Yan X, Zhang H, Lin A et al.

Biology (Basel)(2022)
Animal
PubMed

The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1.

Guo Y, Sun D, Zhang Y et al.

Int Immunopharmacol(2022)
Animal
PubMed

Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model.

Zhang H, Yan X, Lin A et al.

Nutr Neurosci(2023)
Animal
PubMed

Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.

Islam MN, Zhang W, Sakai K et al.

Peptides(2022)
Animal
Glycemic ControlLiver Protection
PubMed

Enteral nutrition alleviated lipopolysaccharides-induced hypercatabolism through ghrelin/GHS-R1α-POMC.

Cao C, Zhang Y, Zuo S et al.

Biochem Biophys Res Commun(2022)
Animal
PubMed

Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken.

Farrokhi R, Babapour V, Zendehdel M et al.

Arch Razi Inst(2021)
Animal
Neuroprotection
PubMed

Antagonism of the ghrelin receptor type 1a in the rat brain induces status epilepticus in an electrical kindling model of epilepsy.

Azimzadeh M, Beheshti S

Psychopharmacology (Berl)(2022)
Animal
PubMed

Ghrelin receptor antagonist attenuated sickness behavior and activation of HPA-axis induced by immunological challenge in male rats.

Paula DE Jr, Vilela FC, Giusti-Paiva A

Life Sci(2022)
Animal
PubMed

Therapeutic effects of acylated ghrelin-specific receptor GHS-R1a antagonist in islet transplantation.

Chinen K, Sakata N, Yoshimatsu G et al.

Sci Rep(2021)
Animal
PubMed
Back to GHRP-6 Research Overview

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