Back to GHRP-2

INDEXED STUDIES

GHRP-2 — Indexed Studies

61 most recent studies indexed by PSI from PubMed and clinical databases

Showing 61 of 61 studies

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone.

Otsuka Y, Soejima Y, Nakano Y et al.

Int J Mol Sci(2026)
Human
PubMed

Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.

Seki Y, Ichihara A

PLoS One(2022)
Human
GH Activity
PubMed

ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.

Naito K, Suzuki S, Ohwada C et al.

AACE Clin Case Rep(2021)
Human
PubMed

Refractory hypoglycaemia in a localised gastrointestinal stromal tumour: Case report.

Dhali A, Ray S, Dhali GK et al.

Int J Surg Case Rep(2021)
Human
PubMed

Preoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas.

Soga A, Fukuda I, Kobayashi S et al.

Endocr J(2020)
Human
GH Activity
PubMed

Idiopathic and isolated adrenocorticotropic hormone deficiency presenting as continuous epigastric discomfort without symptoms of hypoglycemia: a case report.

Okauchi S, Tatsumi F, Kan Y et al.

J Med Case Rep(2019)
Human
Anti-Inflammatory
PubMed

Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma.

Seki T, Yasuda A, Oki M et al.

Tokai J Exp Clin Med(2017)
Human
PubMed

Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients.

Ohara E, Tokuyama H, Kitamoto T et al.

Obes Surg(2017)
Human
GH ActivityWeight Loss
PubMed

Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure.

Arimura H, Hashiguchi H, Yamamoto K et al.

Endocr J(2016)
Human
GH Activity
PubMed

Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation.

Hu R, Wang Z, Peng Q et al.

PLoS One(2016)
Human
Weight LossGH ActivityMuscle Recovery
PubMed

One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient.

Haruta I, Fuku Y, Kinoshita K et al.

J Cachexia Sarcopenia Muscle(2015)
Human
PubMed

Estradiol regulates GH-releasing peptide's interactions with GH-releasing hormone and somatostatin in postmenopausal women.

Norman C, Rollene NL, Erickson D et al.

Eur J Endocrinol(2014)
Human
Weight LossGH Activity
PubMed

Differential pulsatile secretagogue control of GH secretion in healthy men.

Norman C, Miles J, Bowers CY et al.

Am J Physiol Regul Integr Comp Physiol(2013)
Human
Weight LossGH Activity
PubMed

Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency.

Hirohata T, Saito N, Takano K et al.

Endocr J(2013)
Human
GH Activity
PubMed

The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: a comparison.

Kinoshita Y, Tominaga A, Usui S et al.

Endocr J(2013)
Human
GH Activity
PubMed

Regulated recovery of pulsatile growth hormone secretion from negative feedback: a preclinical investigation.

Veldhuis JD, Bowers CY

Am J Physiol Regul Integr Comp Physiol(2011)
Human
Weight LossGH Activity
PubMed

Gender, sex-steroid, and secretagogue-selective recovery from growth hormone-induced feedback in older women and men.

Veldhuis JD, Erickson D, Wigham J et al.

J Clin Endocrinol Metab(2011)
Human
GH Activity
PubMed

Complex regulation of GH autofeedback under dual-peptide drive: studies under a pharmacological GH and sex steroid clamp.

Veldhuis JD, Erickson D, Miles JM et al.

Am J Physiol Endocrinol Metab(2011)
Human
Weight LossGH Activity
PubMed

Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2.

Kimura T, Shimatsu A, Arimura H et al.

Endocr J(2010)
Human
PubMed

Secretagogue type, sex-steroid milieu, and abdominal visceral adiposity individually determine secretagogue-stimulated cortisol secretion.

Iranmanesh A, Bowers CY, Veldhuis JD

Eur J Endocrinol(2010)
Human
GH Activity
PubMed

Comparison of pituitary-adrenal responsiveness between insulin tolerance test and growth hormone-releasing peptide-2 test: a pilot study.

Kano T, Sugihara H, Sudo M et al.

Peptides(2010)
Human
PubMed

Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp.

Hudson SB, Schroeder DR, Bailey JN et al.

J Clin Endocrinol Metab(2010)
Human
GH Activity
PubMed

Exaggerated response of adrenocorticotropic hormone to growth hormone-releasing peptide-2 test in Cushing's disease. Case report.

Sakihara S, Kageyama K, Matsumoto A et al.

Neurol Med Chir (Tokyo)(2009)
Human
PubMed

Relative effects of estrogen, age, and visceral fat on pulsatile growth hormone secretion in healthy women.

Veldhuis JD, Hudson SB, Erickson D et al.

Am J Physiol Endocrinol Metab(2009)
Human
LongevityGH Activity
PubMed

Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism.

Veldhuis JD, Keenan DM, Bailey JN et al.

Eur J Endocrinol(2009)
Human
GH Activity
PubMed

Factors other than sex steroids modulate GHRH and GHRP-2 efficacies in men: evaluation using a GnRH agonist/testosterone clamp.

Veldhuis JD, Bowers CY

J Clin Endocrinol Metab(2009)
Human
GH Activity
PubMed

Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp.

Veldhuis JD, Keenan DM, Bailey JN et al.

J Clin Endocrinol Metab(2009)
Human
LongevityGH Activity
PubMed

Determinants of GH-releasing hormone and GH-releasing peptide synergy in men.

Veldhuis JD, Bowers CY

Am J Physiol Endocrinol Metab(2009)
Human
GH Activity
PubMed

Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men.

Veldhuis JD, Mielke KL, Cosma M et al.

J Clin Endocrinol Metab(2009)
Human
GH Activity
PubMed

Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men.

Veldhuis JD, Keenan DM

Eur J Endocrinol(2008)
Human
GH Activity
PubMed

Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men.

Paulo RC, Cosma M, Soares-Welch C et al.

J Clin Endocrinol Metab(2008)
Human
Weight LossGH Activity
PubMed

Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women.

Veldhuis JD, Keenan DM, Bowers CY

Am J Physiol Regul Integr Comp Physiol(2007)
Human
GH Activity
PubMed

A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency.

Chihara K, Shimatsu A, Hizuka N et al.

Eur J Endocrinol(2007)
Human
PubMed

Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model.

Veldhuis JD, Keenan DM, Bowers CY

Am J Physiol Regul Integr Comp Physiol(2007)
Human
GH Activity
PubMed

Tripartite control of growth hormone secretion in women during controlled estradiol repletion.

Veldhuis JD, Cosma M, Erickson D et al.

J Clin Endocrinol Metab(2007)
Human
LongevityGH Activity
PubMed

GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome.

Salvatori R, Serpa MG, Parmigiani G et al.

J Endocrinol Invest(2006)
Human
Glycemic ControlGH Activity
PubMed

Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.

Laferrère B, Hart AB, Bowers CY

Obesity (Silver Spring)(2006)
Human
Appetite RegulationGH ActivityWeight Loss
PubMed

Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.

Veldhuis JD, Keenan DM, Mielke K et al.

Eur J Endocrinol(2005)
Human
LongevityGH Activity
PubMed

Short-term testosterone supplementation does not activate GH and IGF-I production in postmenopausal women.

Soares-Welch C, Mielke KL, Bowers CY et al.

Clin Endocrinol (Oxf)(2005)
Human
GH Activity
PubMed

Joint mechanisms of impaired growth-hormone pulse renewal in aging men.

Veldhuis JD, Iranmanesh A, Bowers CY

J Clin Endocrinol Metab(2005)
Human
LongevityGH Activity
PubMed

Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp.

Erickson D, Keenan DM, Farhy L et al.

J Clin Endocrinol Metab(2005)
Human
GH Activity
PubMed

Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults.

Veldhuis JD, Patrie JT, Brill KT et al.

J Clin Endocrinol Metab(2004)
Human
LongevityGH Activity
PubMed

Activation of somatostatin-receptor subtype-2/-5 suppresses the mass, frequency, and irregularity of growth hormone (GH)-releasing peptide-2-stimulated GH secretion in men.

Iranmanesh A, Bowers CY, Veldhuis JD

J Clin Endocrinol Metab(2004)
Human
GH Activity
PubMed

Short-term testosterone supplementation relieves growth hormone autonegative feedback in men.

Veldhuis JD, Evans WS, Iranmanesh A et al.

J Clin Endocrinol Metab(2004)
Human
GH Activity
PubMed

Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children.

Mericq V, Cassorla F, Bowers CY et al.

J Pediatr Endocrinol Metab(2003)
Human
Appetite RegulationWeight LossGH Activity
PubMed

Pulsatile and nocturnal growth hormone secretions in men do not require periodic declines of somatostatin.

Dimaraki EV, Jaffe CA, Bowers CY et al.

Am J Physiol Endocrinol Metab(2003)
Human
GH Activity
PubMed

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone.

Van den Berghe G, Baxter RC, Weekers F et al.

Clin Endocrinol (Oxf)(2002)
Human
GH Activity
PubMed

Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women.

Veldhuis JD, Evans WS, Bowers CY

J Clin Endocrinol Metab(2002)
Human
GH Activity
PubMed

E2 supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion.

Anderson SM, Wideman L, Patrie JT et al.

J Clin Endocrinol Metab(2001)
Human
GH Activity
PubMed

Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor.

Gondo RG, Aguiar-Oliveira MH, Hayashida CY et al.

J Clin Endocrinol Metab(2001)
Human
GH Activity
PubMed

Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.

Roelfsema F, Biermasz NR, Veldman RG et al.

J Clin Endocrinol Metab(2001)
Human
GH Activity
PubMed

Growth hormone/insulin-like growth factor-1 response to acute and chronic growth hormone-releasing peptide-2, growth hormone-releasing hormone 1-44NH2 and in combination in older men and women with decreased growth hormone secretion.

Bowers CY, Granda-Ayala R

Endocrine(2001)
Human
GH Activity
PubMed

Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men.

Van Dam PS, Smid HE, de Vries WR et al.

J Clin Endocrinol Metab(2000)
Human
Glycemic ControlGH ActivityWeight Loss
PubMed

Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.

Wideman L, Weltman JY, Patrie JT et al.

Am J Physiol Regul Integr Comp Physiol(2000)
Human
GH Activity
PubMed

Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: influence of gender.

Wideman L, Weltman JY, Patrie JT et al.

Am J Physiol Regul Integr Comp Physiol(2000)
Human
GH Activity
PubMed

Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women.

Shah N, Evans WS, Bowers CY et al.

J Clin Endocrinol Metab(2000)
Human
GH Activity
PubMed

A paradoxical gender dissociation within the growth hormone/insulin-like growth factor I axis during protracted critical illness.

Van den Berghe G, Baxter RC, Weekers F et al.

J Clin Endocrinol Metab(2000)
Human
GH Activity
PubMed

Tripartite neuroendocrine activation of the human growth hormone (GH) axis in women by continuous 24-hour GH-releasing peptide infusion: pulsatile, entropic, and nyctohemeral mechanisms.

Shah N, Evans WS, Bowers CY et al.

J Clin Endocrinol Metab(1999)
Human
GH Activity
PubMed

Preservation of growth hormone secretion in response to growth hormone-releasing peptide-2 during prednisone therapy.

Meacham LR, Culler FL, Abdul-Latif H et al.

Metabolism(1999)
Human
Anti-InflammatoryGH Activity
PubMed

Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness.

Van den Berghe G, Wouters P, Weekers F et al.

J Clin Endocrinol Metab(1999)
Human
Bone HealingGH Activity
PubMed

Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.

Arvat E, Di Vito L, Lanfranco F et al.

J Endocrinol Invest(1999)
Human
GH Activity
PubMed
Back to GHRP-2 Research Overview

Considering peptide therapy?

Find a vetted physician in our directory who specializes in evidence-based peptide protocols.

Find a Physician