Research Index
GHK-Cu Research Index
PSI surfaces 50 peer-reviewed studies on GHK-Cu, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials.
Najafi N, Maatouk H, Vardanyan KG et al.
Arch Intern Med Res·2026·Animal·PubMed →
The Regenerative Potential of GHK-Cu in Aesthetic Medicine.
Mokhtar J, Mohamad B, Haddad J et al.
Aesthet Surg J·2026·Animal·PubMed →
A tea exosome-integrated self‑oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing.
Xie LH, Zhou XH, Wen WQ et al.
Carbohydr Polym·2026·Animal·Wound Healing, Antimicrobial·PubMed →
Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
Tewari K, Liu TP, Im C et al.
Am J Sports Med·2026·Animal·PubMed →
Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu.
Wang J, Tao K, Huang H et al.
Skin Res Technol·2026·Animal·Skin & Cosmetic, Wound Healing·PubMed →
A Torilis japonica Extract-GHK-Cu Complex Attenuates Th2 Cytokines and Promotes Keratinocyte Recovery: A Potential Antioxidant Strategy for Atopic Dermatitis.
Jeon S, Maeng J, Lee J et al.
Antioxidants (Basel)·2026·Animal·PubMed →
Copper peptide activated cascade catalysis for glucose regulation and hypoxia reversing in infected diabetic wound healing.
Huang ZJ, Huang RF, Jiao PP et al.
Mater Today Bio·2026·Animal·PubMed →
Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres.
Su J, Zhang Y, Cao Y et al.
Biomater Adv·2026·Animal·Tissue Remodeling·PubMed →
Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs.
Mazzola J, Rosenfeld M, Tucker M et al.
Res Sq·2026·Animal·PubMed →
The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways.
Wen H, Zhao K, Luo X et al.
Biogerontology·2026·Animal·Longevity·PubMed →
Microenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury.
Yu X, Yang T, Bei Z et al.
Bioact Mater·2026·Animal·PubMed →
The Laccase-like Property of GHK-Cu and Its Applications in Colorimetric Sensing of Phenolic Compounds.
Chen JS, Zhu H, Chai TQ et al.
Biosensors (Basel)·2026·Animal·PubMed →
Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model.
Hu J, Zhang C, Wang F
Eur J Pharmacol·2026·Animal·Anti-Inflammatory·PubMed →
Carbonless amino acids and a carbonless GHK peptide.
Skurski P, Anusiewicz I
Phys Chem Chem Phys·2026·Animal·PubMed →
Glycyl-l-histidyl-l-lysine as a novel co-former in co-amorphous systems: Enhanced aqueous solubility and physical stability.
Huang Q, Zou Z, Cheng D et al.
Eur J Pharm Sci·2026·Animal·PubMed →
Golgi-targeted copper delivery strategy via enhancing copper-dependent proteins' activity for fascia regeneration.
Wang R, Xu Y, Saiding Q et al.
J Control Release·2026·Animal·Tissue Remodeling·PubMed →
Anxiolytic Effect of GHK-PGP Peptide and Its Structural Analogues in a Test with Punished Behavior.
Alferova ME, Bobyntsev II, Vorvul AO et al.
Bull Exp Biol Med·2025·Animal·PubMed →
An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.
Hu D, Zhang X, Gong S et al.
Colloids Surf B Biointerfaces·2025·Animal·Anti-Inflammatory·PubMed →
Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.
Mao S, Huang J, Li J et al.
Front Pharmacol·2025·Animal·PubMed →
Interaction of half-sandwich Rh(III) ion and some of its complexes with endogenous imidazole derivatives.
Hassoon AA, Szorcsik A, Gajda T
J Inorg Biochem·2025·Animal·PubMed →
Intrinsically photoluminescent hydrogels to measure peptides‑copper binding affinities.
Distefano A, Corsaro P, Tuccitto N et al.
J Inorg Biochem·2025·Animal·PubMed →
Copper Complexes with New Glycyl-l-histidyl-l-lysine-Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects.
Greco V, Lanza V, Tomasello B et al.
Bioconjug Chem·2025·Animal·Tissue Remodeling·PubMed →
Self-Assembled Peptide-Gold Nanoparticle 1D Nanohybrids Functionalized with GHK Tripeptide for Enhanced Wound-Healing and Photothermal Therapy.
Jeon N, Kim L, Choi SG et al.
ACS Appl Mater Interfaces·2025·Animal·Wound Healing·PubMed →
Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing.
Castro VIB, Araújo AR, Reis RL et al.
ACS Appl Mater Interfaces·2025·Animal·Wound Healing·PubMed →
Food-Derived Tripeptide-Copper Self-Healing Hydrogel for Infected Wound Healing.
Chen H, Yang P, Xue P et al.
Biomater Res·2025·Animal·PubMed →
Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines.
Hong M, Gui Y, Xu J et al.
Biochem Biophys Res Commun·2025·Animal·PubMed →
Novel Applications of CE-ICP-MS/MS: Monitoring of Antiaging GHK-Cu Cosmetic Component Encapsulation in Liposomes.
Zajda J, Wadych E, Ogórek K et al.
Electrophoresis·2024·Animal·Skin & Cosmetic·PubMed →
The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.
Bian Y, Deng M, Liu J et al.
Redox Biol·2024·Animal·PubMed →
Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro.
Min JH, Sarlus H, Harris RA
Metallomics·2024·Animal·Neuroprotection·PubMed →
Rigid-flexible nanocarriers loaded with active peptides for antioxidant and anti-inflammatory applications in skin.
Wang Y, Lin J, Yu Z et al.
Colloids Surf B Biointerfaces·2024·Animal·Wound Healing, Anti-Inflammatory·PubMed →
Effects of Gly-His-Lys-D-Ala Peptide on Skin Wound Regeneration Processes.
Rakhmetova KK, Mishina ES, Bobyntsev II et al.
Bull Exp Biol Med·2024·Animal·PubMed →
Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide.
Tucker M, Liao GY, Keely A et al.
Aging Pathobiol Ther·2024·Animal·PubMed →
Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application.
Liu T, Liu Y, Zhao X et al.
Bioact Mater·2024·Animal·PubMed →
Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide.
Tucker M, Liao GY, Park JY et al.
bioRxiv·2023·Animal·PubMed →
Intranasal GHK peptide enhances resilience to cognitive decline in aging mice.
Tucker M, Keely A, Park JY et al.
bioRxiv·2023·Animal·PubMed →
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.
Dymek M, Olechowska K, Hąc-Wydro K et al.
Pharmaceutics·2023·Animal·PubMed →
In situ photo-crosslinkable hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers for bioactive wound healing.
Lee S, Lee SM, Lee SH et al.
Acta Biomater·2023·Animal·Wound Healing, Tissue Remodeling·PubMed →
Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications.
Sahu R, Yadav S, Gunturu KC et al.
J Org Chem·2023·Animal·PubMed →
New Biotinylated GHK and Related Copper(II) Complex: Antioxidant and Antiglycant Properties In Vitro against Neurodegenerative Disorders.
Tosto R, Vecchio G, Bellia F
Molecules·2023·Animal·PubMed →
Ultrasensitive and Label-Free Detection of Copper Ions by GHK-Modified Asymmetric Nanochannels.
An P, Zhang Z, Yang J et al.
Anal Chem·2023·Animal·PubMed →
Multi working mode SPR chip laboratory for high refractive index detection.
Ren Z, Liu C, Wei Y et al.
Opt Express·2023·Animal·PubMed →
Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex via activation of SIRT1 in airway epithelial cells.
Zhang Q, Liu J, Deng MM et al.
Biomed Pharmacother·2023·Animal·PubMed →
Improved laccase production by Trametes versicolor using Copper-Glycyl-L-Histidyl-L-Lysine as a novel and high-efficient inducer.
Wang F, Yu X, Yu Z et al.
Front Bioeng Biotechnol·2023·Animal·PubMed →
Differential Effects of Histidine and Histidinamide versus Cysteine and Cysteinamide on Copper Ion-Induced Oxidative Stress and Cytotoxicity in HaCaT Keratinocytes.
Ha JW, Choi JY, Boo YC
Antioxidants (Basel)·2023·Animal·PubMed →
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.
Jiang F, Wu Y, Liu Z et al.
J Cosmet Dermatol·2023·Animal·Tissue Remodeling·PubMed →
Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.
Deng M, Zhang Q, Yan L et al.
J Cachexia Sarcopenia Muscle·2023·Animal·Muscle Recovery·PubMed →
Combination Tripeptide/Hexapeptide Serum with 1540 nm Nonablative Fractional Laser for the Treatment of Striae Distensae: A Pilot Study.
McGuinn KP, Ross NA, Wang JV et al.
Skinmed·2020·Human·PubMed →
Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits.
Cangul IT, Gul NY, Topal A et al.
Vet Dermatol·2006·Human·Wound Healing·PubMed →
Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin.
Miller TR, Wagner JD, Baack BR et al.
Arch Facial Plast Surg·2006·Human·Wound Healing·PubMed →
A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers.
Bishop JB, Phillips LG, Mustoe TA et al.
J Vasc Surg·1992·Human·Wound Healing·PubMed →