Research Index
FOXO4-DRI Research Index
PSI surfaces 12 peer-reviewed studies on FOXO4-DRI, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
12 studies
Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
Alameen AAM, Al-Kuraishy HM, Fawzy MN et al.
Naunyn Schmiedebergs Arch Pharmacol·2026·Review·Longevity·PubMed →
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
Hu Z, Li F, Hu C et al.
Front Bioeng Biotechnol·2025·Animal·PubMed →
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Bourgeois B, Spreitzer E, Platero-Rochart D et al.
Nat Commun·2025·Animal·Longevity·PubMed →
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
Kong YX, Li ZS, Liu YB et al.
Commun Biol·2025·Animal·Tissue Remodeling, Longevity·PubMed →
FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.
Liu Y, Hou Q, Wang R et al.
Naunyn Schmiedebergs Arch Pharmacol·2023·Animal·Tissue Remodeling·PubMed →
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Born E, Lipskaia L, Breau M et al.
Circulation·2023·Animal·PubMed →
FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway.
Han X, Yuan T, Zhang J et al.
J Cell Mol Med·2022·Animal·PubMed →
Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
Meng J, Li Y, Wan C et al.
JCI Insight·2021·Animal·Longevity, Tissue Remodeling·PubMed →
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.
Huang Y, He Y, Makarcyzk MJ et al.
Front Bioeng Biotechnol·2021·Animal·PubMed →
Cellular senescence in the aging and diseased kidney.
Valentijn FA, Falke LL, Nguyen TQ et al.
J Cell Commun Signal·2018·Review·PubMed →
Rejuvenation by Therapeutic Elimination of Senescent Cells.
Krimpenfort P, Berns A
Cell·2017·Animal·PubMed →
[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine].
Liu BH, Gu YH, Tu Y et al.
Zhongguo Zhong Yao Za Zhi·2017 ·Review·Longevity·PubMed →