Research Index
Epitalon Research Index
PSI surfaces 50 peer-reviewed studies on Epitalon, prioritized by evidence strength: human clinical research first, then animal studies. The full historical archive is linked below on PubMed.
50 studies
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S, Thomas R, Matta S et al.
Biogerontology·2025·Animal·PubMed →
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Gatta M, Dovizio M, Milillo C et al.
Stem Cell Rev Rep·2025·Animal·Wound Healing·PubMed →
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Ullah S, Haider Z, Perera CD et al.
Life Sci·2025·Animal·Longevity·PubMed →
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
Yue X, Liu SL, Guo JN et al.
Aging (Albany NY)·2022·Animal·Longevity·PubMed →
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
Avolio F, Martinotti S, Khavinson VK et al.
Int J Mol Sci·2022·Animal·Anti-Inflammatory·PubMed →
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Khavinson V, Diomede F, Mironova E et al.
Molecules·2020·Animal·Neuroprotection·PubMed →
Effect of short peptides on neuronal differentiation of stem cells.
Caputi S, Trubiani O, Sinjari B et al.
Int J Immunopathol Pharmacol·2019·Animal·Neuroprotection·PubMed →
[GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].
Jokhadze T, Monaselidze J, Nemsadze G et al.
Georgian Med News·2017·Human·PubMed →
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland.
Khavinson VK, Kopylov AT, Vaskovsky BV et al.
Bull Exp Biol Med·2017·Animal·PubMed →
Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan.
Khavinson VK, Kormilets DY, Mar'yanovich AT
Bull Exp Biol Med·2017·Animal·PubMed →
Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro.
Lin'kova NS, Drobintseva AO, Orlova OA et al.
Bull Exp Biol Med·2016·Animal·Longevity, Tissue Remodeling·PubMed →
Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
Morozov AV, Khizhkin EA, Svechkina EB et al.
Bull Exp Biol Med·2015·Animal·Longevity·PubMed →
Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations.
Vanhee C, Moens G, Van Hoeck E et al.
Drug Test Anal·2015·Animal·Longevity·PubMed →
[Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].
Zamorskiĭ II, Shchudrova TS
Biofizika·2014·Animal·PubMed →
[Short peptides stimulate skin cell regeneration during ageing].
Chalisova NI, Lin'kova NS, Zhekalov AN et al.
Adv Gerontol·2014·Animal·Longevity, Tissue Remodeling, Wound Healing, Skin & Cosmetic·PubMed →
[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN et al.
Georgian Med News·2013·Human·PubMed →
[Genome instability in pulmonary tuberculosis before and after treatment].
Dzhokhadze TA, Buadze TZh, Rubanov KD et al.
Georgian Med News·2013·Animal·PubMed →
Effect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds.
Pateyk AV, Baranchugova LM, Rusaeva NS et al.
Bull Exp Biol Med·2013·Animal·Longevity, Immune Modulation·PubMed →
Short cell-penetrating peptides: a model of interactions with gene promoter sites.
Khavinson VKh, Tarnovskaya SI, Linkova NS et al.
Bull Exp Biol Med·2013·Animal·PubMed →
[Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].
Korenevsky AV, Milyutina YP, Bukalyov AV et al.
Adv Gerontol·2013·Animal·PubMed →
Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
Arutjunyan A, Kozina L, Milyutina Y et al.
Curr Aging Sci·2012·Animal·Longevity, Neuroprotection·PubMed →
Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.
Khavinson VKh, Linkova NS, Kvetnoy IM et al.
Bull Exp Biol Med·2012·Animal·PubMed →
Effect of short peptides on expression of signaling molecules in organotypic pineal cell culture.
Khavinson VKh, Linkova NS, Chalisova NI et al.
Bull Exp Biol Med·2011·Animal·PubMed →
Peptidegic stimulation of differentiation of pineal immune cells.
Linkova NS, Khavinson VKh, Chalisova NI et al.
Bull Exp Biol Med·2011·Animal·PubMed →
Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens.
Kuznik BI, Pateyuk AV, Rusaeva NS et al.
Bull Exp Biol Med·2011·Animal·PubMed →
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Fedoreyeva LI, Kireev II, Khavinson VKh et al.
Biochemistry (Mosc)·2011·Animal·PubMed →
[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].
Kuznik BI, Pateiuk AV, Rusaeva NS et al.
Adv Gerontol·2011·Animal·Longevity·PubMed →
Biological stability evaluation of the α2β1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide.
Huang CW, Li Z, Cai H et al.
Bioconjug Chem·2011·Animal·PubMed →
[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds].
Kuznik BI, Pateiuk AV, Rusaeva NS et al.
Patol Fiziol Eksp Ter·2010·Animal·PubMed →
[Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes].
Vinogradova IA
Adv Gerontol·2009·Animal·Longevity·PubMed →
[The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].
Dzhokhadze TA, Ganozishvili MN, Lezhava TA
Georgian Med News·2008·Human·PubMed →
Melting of DNA double strand after binding to geroprotective tetrapeptide.
Khavinson VKh, Solovyov AY, Shataeva LK
Bull Exp Biol Med·2008·Animal·PubMed →
Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Vinogradova IA, Bukalev AV, Zabezhinski MA et al.
Bull Exp Biol Med·2008·Animal·Longevity·PubMed →
Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.
Kuznik BI, Pateyuk AV, Rusaeva NS
Bull Exp Biol Med·2008·Animal·PubMed →
Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.
Barabanova SV, Artyukhina ZE, Ovchinnikova KT et al.
Neurosci Behav Physiol·2008·Animal·Anxiety & Mood·PubMed →
[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].
Uzenbaeva LB, Vinogradova IA, Golubeva AG et al.
Adv Gerontol·2008·Animal·Longevity·PubMed →
[The influences of geroprotectors on age-related changes of antioxidant system in rats liver under different light condition].
Il'ina TN, Vinogradova IA, Iliukha VA et al.
Adv Gerontol·2008·Animal·Longevity, Liver Protection·PubMed →
[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].
Kuznik BI, Pateiuk AV, Baranchugova LM et al.
Adv Gerontol·2008·Animal·Longevity, Immune Modulation·PubMed →
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Vinogradova IA, Bukalev AV, Zabezhinski MA et al.
Bull Exp Biol Med·2007·Animal·PubMed →
[The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area].
Miliutina IuP, Kozina LS, Arutiunian AV et al.
Adv Gerontol·2007·Animal·Longevity·PubMed →
[Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].
Labunets' IF
Fiziol Zh (1994)·2007·Animal·Longevity·PubMed →
[Effect of pineal gland peptides on morphofunctional structure of the pancreas in ageing].
Ryzhak AP, Kostiuchek IN, Kvetnoĭ IM
Adv Gerontol·2007·Animal·PubMed →
Effects of bioactive tetrapeptides on free-radical processes.
Kozina LS
Bull Exp Biol Med·2007·Animal·PubMed →
[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people].
Korkushko OV, Lapin BA, Goncharova ND et al.
Adv Gerontol·2007·Animal·Longevity·PubMed →
[Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations].
Vingradova IA, Iliukha VA, Fedorova AS et al.
Adv Gerontol·2007·Animal·Longevity, Muscle Recovery·PubMed →
Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Sibarov DA, Vol'nova AB, Frolov DS et al.
Neurosci Behav Physiol·2007·Animal·Neuroprotection·PubMed →
[Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence].
Barabanova SV, Artiukhina ZE, Ovchinnikova KT et al.
Ross Fiziol Zh Im I M Sechenova·2007·Animal·PubMed →
Antioxidant properties of geroprotective peptides of the pineal gland.
Kozina LS, Arutjunyan AV, Khavinson VKh
Arch Gerontol Geriatr·2007·Animal·PubMed →
Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides.
Gumen AV, Kozinets IA, Shanin SN et al.
Bull Exp Biol Med·2006·Animal·Longevity·PubMed →
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Khavinson V, Razumovsky M, Trofimova S et al.
Neuro Endocrinol Lett·2002·Human·PubMed →