Copper Peptides — Indexed Studies

Genetic inhibition of nicotinamide N-methyltransferase and prevention of alcohol-associated fatty liver in humans.

Wu B, Weng X, Pan Y et al.

Efficacious Anti-Cancer Drugs Targeting Nicotinamide N-Methyltransferase (NNMT) in Cultured Human Oral Squamous Cell Carcinoma (OSCC).

Maloney B, Kubisztal M, Ge Z et al.

Colony-stimulating factor-2 triggers NNMT-dependent myofibroblast activation in head and neck cancer.

Li R, Yang X, Li Y et al.

Detachment-Induced FAK-STAT3-NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation.

Tong Q, Ma Y, Gao Y et al.

Construction and initial validation of key gene network for progesterone resistance in endometrial cancer based on genome-wide CRISPR screening.

Li X, Wang S, Qiu Z et al.

Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer.

Carreira ÁSA, Ciuffreda M, Thongon N et al.

NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease.

Chanvillard L, Lantermans HC, Wall C et al.

Erianin Abrogates Cancerous Vasculogenic Mimicry Through Targeting m5C Methylase NSUN2 in Uveal Melanoma.

Zuo S, Ho SI, Li L et al.

Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Enzyme for the Treatment of Osteosarcoma and Merkel Cell Carcinoma: Potential for the Development of a Targeted Therapeutic Strategy.

Pompei V, Cecati M, Serritelli EN et al.

Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.

Chen C, Tao M, Wang L et al.

NNMT Orchestrates Metabolic-Epigenetic Reprogramming to Drive Macrophage-Myofibroblast Transition in Hypertrophic Scarring.

Dong X, Guo W, Qian Y et al.

Upregulated NNMT sustains angiogenesis in clear cell renal cell carcinoma through activation of the SDF-1/CXCR4-ERK-CCL20 axis.

Zhang W, Yu Y, Geng B et al.

Nicotinamide N-methyltransferase inhibition improves limb function in experimental peripheral artery disease.

Dong G, Choi J, Li Y et al.

Combination therapy with nisin, urolithin B, and vincristine exhibits synergistic antiproliferative and pro-apoptotic effects against human lymphoma cells: evidence from proteomics.

Al-Khazaleh AK, Alsherbiny MA, Chang D et al.

Insufficient NNMT promotes autophagy and disrupts progesterone signaling in endometrial stromal cells in recurrent implantation failure by modulating the H3K9me3-ALDH1A3 pathway.

Song Y, Zhao S, Hou X et al.

Identification of novel Piperazine based bisubstrate inhibitors of human nicotinamide N-methyltransferase (hNNMT) with potential anticancer activities.

Harikrishna AS, Kesavan V

NAD Metabolism Regulates Proliferation of Macrophages in Atherosclerosis.

Sinha SK, Swichkow CR, Farahi L et al.

NNMT enhances invasive and migratory capacity of keloid fibroblasts and M2 macrophage polarization.

Yan C, Dong H, Li Z et al.

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity.

Heide J, Bilecz AJ, Patnaik S et al.

Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.

Wang S, Ye G, Xu X et al.

NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment.

Ghezzi B, Fiorilla I, Carreira Á et al.

Nicotinamide N-methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling.

Hou Z, Wang Z, Yang F et al.

1-methylnicotinamide attenuated inflammation and regulated flora in Necrotizing enterocolitis.

Hou L, Du J, Li J et al.

Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects.

Hara T, Meng S, Kasahara Y et al.

Depleting the Action of EZH2 through PI3K-mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer.

Melino M, Tu WJ, Bielefeldt-Ohmann H et al.

Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model.

Li S, Rodrigues PG, Chakraborty AD et al.

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves' Orbitopathy.

Cho D, Choi SH, Yoon JS et al.

Downregulation of NNMT affects trophoblast function via inhibiting COMP/CD36/ERK1/2 axis in recurrent spontaneous abortion.

Huang J, Wan Z, Li J et al.

Mechanism and kinetics of turnover inhibitors of nicotinamide N-methyl transferase in vitro and in vivo.

Akerud T, De Fusco C, Brandt P et al.

Machine learning analysis identified NNMT as a potential therapeutic target for hepatocellular carcinoma based on PCD-related genes.

Wei F, Huang P, Zhang B et al.

Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?

Ailabouni AS, Vijaywargi G, Subash S et al.

NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis.

Huang W, Song C, Hua Y et al.

PRDX6 Prevents NNMT Ubiquitination and Degradation as a Nonenzymatic Mechanism to Promote Ovarian Cancer Progression.

Wu X, Luo L, Wang M et al.

Increasing cellular NAD(+) protects hepatocytes against palmitate-induced lipotoxicity by preventing PARP-1 inhibition and the mTORC1-p300 pathway activation.

Guo R, Li Y, Song Q et al.

NNMT suppresses H3K9me3 to facilitate malignant progression and drug resistance in gastric cancer.

Wang B, Wu T

m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization.

Mak TK, Li K, Zhao Z et al.

PI(4,5)P2 alleviates colitis by inhibiting intestinal epithelial cell pyroptosis through NNMT-mediated RBP4 m6A modification.

Yang Q, Diao N, Ma F et al.

Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis.

Hou S, Xu H, Lei S et al.

Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression.

Xiao G, Tang S, Zhang Y et al.

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction.

Babula JJ, Bui D, Stevenson HL et al.

Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.

Wang J, Zhang M, You X et al.

Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice.

Dimet-Wiley AL, Latham CM, Brightwell CR et al.

Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia.

Liang R, Xiang Q, Dai M et al.

Fibroblast regulates angiogenesis in assembled oral cancer organoid: A possible role of NNMT.

Holkom M, Yang X, Li R et al.

Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis.

Yan J, Zhou L, Liu M et al.

Multi-omics analysis reveals NNMT as a master metabolic regulator of metastasis in esophageal squamous cell carcinoma.

Huang Q, Chen H, Yin D et al.

Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function.

Zhang Q, Li Z, Li Q et al.

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1.

Rodríguez-Agudo R, González-Recio I, Serrano-Maciá M et al.

Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications.

Li P, Xia C, Kong X et al.

Structure-Activity Relationship Studies on Cell-Potent Nicotinamide N-Methyltransferase Bisubstrate Inhibitors.

Iyamu ID, Zhao T, Huang R